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Publications

2025

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  1. Liao P., Zhou Y., Qiu Y., Hu R., Li H., Sun H. and Li Y., 2025. "Metal-modulated T cell antitumor immunity and emerging metalloimmunotherapy".  Cancer Metastasis Rev 44, 49, doi:  https://doi.org/10.1007/s10555-025-10266-2

  2. Wang C., Wei X., Zhong L., Chan. C.L., Li H, and Sun H. 2025. "Metal-Based Approaches for the Fight against Antimicrobial Resistance: Mechanisms, Opportunities, and Challenges". JACS, 147(15), pp.12361-12380, doi: https://doi.org/10.1021/jacs.4c16035

  3. Mohamad Koohi-Moghadam, Ahmad Mohammadi, Li H, and Sun H., 2025. "Predicting Pore Limiting Diameter in Metal-Organic Frameworks Using Only Metal-Linker Building Blocks". ChemRxiv, doi: 10.26434/chemrxiv-2025-wd5jw

  4. Li J., Wang H., Gao P., Wang R., Chan C.L., Kao R.Y., Li H. and Sun H., "Bismuth drug eradicates multi-drug resistant Burkholderia cepacia complex via aerobic respiration". Chemical Science, doi: https://doi.org/10.1039/D5SC02049B

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2024

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  1. Xia, Y., Wei, X., Gao, P., Wang, C., de Jong, A., Chen, J.H.K., Rodríguez-Sánchez, M.J., Rodríguez-Nogales, A., Diez-Echave, P., Gálvez, J. and García, F., 2024. "Bismuth-based drugs sensitize Pseudomonas aeruginosa to multiple antibiotics by disrupting iron homeostasis". Nature Microbiology, pp.1-14, doi: https://doi.org/10.1038/s41564-024-01807-6

  2. Li, Y.F. and Sun, H. eds., 2024. Applied Metallomics: From Life Sciences to Environmental Sciences. John Wiley & Sons. ISBN: 978-3-527-84038-0

  3. Zhou, Y., Li, H., Tse, E. and Sun, H., 2024. "Metal-detection based techniques and their applications in metallobiology." Chemical Science, 15(27), pp.10264-10280. doi:  10.1039/D4SC00108G

  4. Wei, X., Chan, C.L., Zhou, Y., Tang, K., Chen, J., Wang, S., Chan, J.F.W., Yuan, S., Li, H. and Sun, H., 2024. “Mechanistic insights into bismuth (III) inhibition of SARS-CoV-2 helicase.” Chemical Science, 15, 10065-10072. doi: 10.1039/D3SC06961C

  5. Casini, A., Chao, H., Sun, H. and Chang, C.J., 2024. Introduction to “Chemical biology of metals”. RSC Chemical Biology, 5(6), pp.481-482. doi: 10.1039/D4CB90017K

  6. Shi, L., Lu, J., Xia, X., Liu, X., Li, H., Li, X., Zhu, J., Li, X., Sun, H. and Yang, X., 2024. "Clinically used drug arsenic trioxide targets XIAP and overcomes apoptosis resistance in an organoid-based preclinical cancer model". Chemical Science.15, 8311-8322. doi: 10.1039/D4SC01294A

  7. Zhou, Y., Cheng, T., Tang, K., Li, H., Luo, C., Yu, F., Xiao, F., Jin, L., Hung, I.F.N., Lu, L. and Yuen, K.Y., 2024. "Integration of metalloproteome and immunoproteome reveals a tight link of iron-related proteins with COVID-19 pathogenesis and immunity". Clinical Immunology, 263, p.110205. doi: 10.1016/j.clim.2024.110205

  8. Chen, J., Zhou, Y., Wei, X., Xu, X., Qin, Z., Ong, C.P., Ye, Z.W., Jin, D.Y., Boitrel, B., Yuan, S. and Chan, J.F.W., 2023. "Development of Pan-Anti-SARS-CoV-2 Agents through Allosteric Inhibition of nsp14/nsp10 Complex". ACS Infectious Diseases, 10(3), pp.858-869. doi: 10.1021/acsinfecdis.3c00356

  9. Zhou, Y., Shen, W., Gao, Y., Peng, J., Li, Q., Wei, X., Liu, S., Lam, F.S., Mayol-Llinàs, J., Zhao, G. and Li, G., 2024. "Protein-templated ligand discovery via the selection of DNA-encoded dynamic libraries". Nature Chemistry, 16(4), pp.543-555. doi: 10.1038/s41557-024-01442-y

  10. Lu, J., Liu, X., Li, X., Li, H., Shi, L., Xia, X., He, B.L., Meyer, T.F., Li, X., Sun, H. and Yang, X., 2024. "Copper regulates the host innate immune response against bacterial infection via activation of ALPK1 kinase". Proceedings of the National Academy of Sciences, 121(4), p.e2311630121. doi: 10.1073/pnas.2311630121

 

2023

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  1. ​Gao, P., Wei, Y., Hou, S., Lai, P.M., Liu, H., Tai, S.S.C., Tang, V.Y.M., Prakash, P.H., Sze, K.H., Chen, J.H.K. and Sun, H., 2023. "SaeR as a novel target for antivirulence therapy against Staphylococcus aureus". Emerging Microbes & Infections, 12(2), p.2254415. doi: 10.1080/22221751.2023.2254415​

  2. Mo, Y., Yue, M., Yim, L.Y., Zhou, R., Yu, C., Peng, Q., Zhou, Y., Luk, T.Y., Lui, G.C.Y., Huang, H. and Lim, C.Y.H., 2023. "Nicotinamide mononucleotide impacts HIV-1 infection by modulating immune activation in T lymphocytes and humanized mice". EBioMedicine, 98. doi: 10.1016/j.ebiom.2023.104877

  3. Zhou Y, Yuan S, Xiao F, Li H, Ye Z, Cheng T, Luo C, Tang K, Cai J, Situ J, Sridhar S, Chu WM, Tam AR, Chu H, Che CM, Jin L, Hung IF, Lu L, Chan JF, Sun H. "Metal-coding assisted serological multi-omics profiling deciphers the role of selenium in COVID-19 immunity". Chemical Science. 2023 Sep 18;14(38):10570-10579. doi: 10.1039/d3sc03345g

  4. Wang, C., Xia, Y., Wang, R., Li, J., Chan, C.L., Kao, R.Y.T., Toy, P.H., Ho, P.L., Li, H. and Sun, H., 2023. "Metallo-sideromycin as a dual functional complex for combating antimicrobial resistance". Nature Communications, 14(1), p.5311. doi: 10.1038/s41467-023-40828-3

  5. He, X., Han, B., Wang, R., Guo, Y., Kao, R.Y., Li, H., Sun, H. and Xia, W., 2023. "Dual-action gallium-flavonoid compounds for combating Pseudomonas aeruginosa infection". RSC Chemical Biology, 4(10), pp.774-784. doi: 10.1039/d3cb00033h

  6. Chen, C., Xu, Y., Oelschlaeger, P., Brem, J., Liu, L., Wang, D., Sun, H. and Yang, K.W., 2023. "A dual covalent binder for labelling and inhibiting serine and metallo-carbapenemases". Chemical Communications, 59(60), pp.9227-9230. doi: 10.1039/d3cc02373g

  7. Ip, T.K.Y., Zhou, Y., Li, H. and Sun, H., 2023. "Metalloproteomics: A Powerful Technique for Metals in Medicine". In Targeted Metallo-Drugs (pp. 265-288). CRC Press. 

  8. ​Bhattarai, A., Lok, J.G.T., Sun, H. and Vardhanabhuti, V., 2023. "Computed Tomography of Cartilage: An Exploration of Novel Cationic Bismuth Contrast Agent". Annals of Biomedical Engineering, 51(5), pp.977-986. doi: 10.1007/s10439-022-03110-z​

  9. Bhattarai, A.; Lok, J. G.-T.; Sun, H.; Vardhanabhuti, V. "Photon counting spectral computed tomography in diagnosis of joint conditions using novel bismuth contrast agent". Medical Imaging 2023: Physics of Medical Imaging, 2023; SPIE: Vol. 12463, pp 20-25. doi: 10.1117/12.2653234

  10. Wang, H.; Hu, L.; Li, H.; Lai, Y.-T.; Wei, X.; Xu, X.; Cao, Z.; Cao, H.; Wan, Q.; Chang, Y.-Y.; Xu, A.; Zhou, Q.; Jiang, G.; He, M.-L.; Sun, H. "Mitochondrial ATP Synthase as a Direct Molecular Target of Chromium(Iii) to Ameliorate Hyperglycaemia Stress". Nature Communications 2023, 14 (1). DOI:10.1038/s41467-023-37351-w.

  11. Yang, P.; Pan, J.; Wang, H.; Xiaohan, X.; Zeling, X.; Chen, X.; Yang, Y.; Sun, H.; Li, M.; Habimana, O. "Structural, Metagenomic and Metabolic Shifts in Multispecies Freshwater Biofilm Models Exposed to Silver Nanoparticles". Journal of Environmental Chemical Engineering 2023, 11 (1), 109162. DOI:10.1016/j.jece.2022.109162.

  12. Huang, R.; Zhou, Z.; Lan, X.; Tang, F. K.; Cheng, T.; Sun, H.; Cham-Fai Leung, K.; Li, X.; Jin, L. "Rapid Synthesis of Bismuth-Organic Frameworks as Selective Antimicrobial Materials against Microbial Biofilms". Materials Today Bio 2023, 18, 100507. DOI:10.1016/j.mtbio.2022.100507.

  13. Zhang, Q.; Wang, M.; Hu, X.; Yan, A.; Ho, P.-L.; Li, H.; Sun, H. "Gold Drugs as Colistin Adjuvants in the Fight against MCR-1 Producing Bacteria". JBIC Journal of Biological Inorganic Chemistry 2023, 28 (2), 225–234. DOI:10.1007/s00775-022-01983-y.

  14. Yan, X.; Zhou, Y.; Li, H.; Jiang, G.; Sun, H. "Metallomics and Metalloproteomics". Comprehensive Inorganic Chemistry III 2023, 53–76. DOI:10.1016/b978-0-12-823144-9.00060-1.

 

2022

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  1. Bhattarai, A.; Lok, J. G.-T.; Sun, H.; Vardhanabhuti, V. "Computed Tomography of Cartilage: An Exploration of Novel Cationic Bismuth Contrast Agent". Annals of Biomedical Engineering 2022, 51 (5), 977–986. DOI:10.1007/s10439-022-03110-z.

  2. Mohamadi, A.; Cheng, T.; Jin, L.; Wang, J.; Sun, H.; Koohi-Moghadam, M. "An Ensemble 3D Deep-Learning Model to Predict Protein Metal-Binding Site". Cell Reports Physical Science 2022, 3 (9), 101046. DOI:10.1016/j.xcrp.2022.101046.

  3. Zhou Y., Li H.Y., Sun H.Z.* "Metalloproteomics for biomedical research: methodology and applications”. Annual Review of Biochemistry (Editor: Kornberg, R.), , doi: 10.1146/annurev-biochem-040320-104628

  4. Zhang Q.§, Wang R.M.§, Wang M.J., Liu C.J., Koohi-Moghadam M., Wang H.B., Ho P.L., Li H.Y., Sun H.Z.* "Re-sensitization of mcr carrying multidrug resistant bacteria to colistin by silver". Proceedings of the National Academy of Sciences USA, 119 (11) e2119417119, doi: 10.1073/pnas.2119417119

  5. Li H.Y., Sun H.Z.* "A hydroxide lock for metallo-β-lactamases" . Nature Chemistry, 14, 6-8, doi: 10.1038/s41557-021-00871-3

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2021

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  1. Wang R.M.§, Chan J.F.W.§, Wang S.Y.§, Li H.Y., Zhao J.J., Ip T.K.Y., Zuo J.Z., Yuen K.Y., Yuan S.F., Sun H.Z.* "Orally administrated bismuth drug together with N-acetyl cysteine as a broad-spectrum anti-coronavirus cocktail therapy". Chemical Science, 13, 2238-2248, doi: 10.1039/D1SC04515F.

  2. Yan X.T.,  Zhou Y., Jiang G.B., Li H.Y., Sun H.Z.* "Metallomics and metalloproteomics", in Comprehensive Inorganic Chemistry III (Editor: Pecoraro, V.P., Guo, Z.J.), accepted

  3. Zhou Y., Tse E.W.C., Leung R., Cheung E., Li H.Y., Sun H.Z.* "Multiplex single-cell analysis of cancer cells enables unbiased uncovering subsets associated with cancer relapse: heterogeneity of multidrug resistance in precursor B-ALL", ChemMedChem, 16, doi: /10.1002/cmdc.202100638.

  4. Wang C., Li X., Cheng T.F., Sun H.Z., Jin L.J.* "Eradication of porphyromonas gingivalis persisters through colloidal bismuth subcitrate synergistically combined with metronidazole", Frontiers in Microbiology, 12, 748121, doi: 10.3389/fmicb.2021.748121.

  5. Li Y.F.*, Sun H.Z. "Metallomics in multidisciplinary research and the analytical advances", Atomic Spectroscopy, 42(5), 227-230, doi: 10.46770/AS.2021.108.

  6. Zhao J.T., Wang L.M., Cui L.W., Sun H.Z.*, Gao Y.X., Li Y.F.* "Metallomics for the screening of COVID-19 and metallodrug development", Atomic Spectrscopy, 42(5), 231-237, doi: 10.46770/AS.2021.805. 

  7. Griffith D.§, Li H.Y.§, Werrett M.W., Andrews P., Sun H.Z.* "Medicinal chemistry and biomedical applications of bismuth-based compounds", Chemical Society Review, 50(21), 12037-12069, doi: 10.1039/D0CS00031K.

  8. Hu X.Q.§, Li H.Y.§, Ip T.K.Y., Cheung Y.F., Koohi-Moghadam M., Wang H.B., Yang X.M., Tritton D. N., Wang Y.C., Wang Y., Wang R.M., Ng K.M., Naranmandura H., Tse E.W.C., Sun H.Z.* "Arsenic trioxide targets Hsp60, triggering degradation of p53 and survivin".  Chemical Science, 12(32), 10893-10900, doi: 10.1039/D1SC03119H

  9. Maimaitiyiming Y., Wang Q.Q., Yang C., Ogra Y., Lou Y.J., Smith C.A., Hussain L., Shao Y.M., Lin J.B., Liu J.F., Wang L.F., Zhu Y., Lou H.Y., Huang Y., Li X.X., Chang K.J., Chen H. Li H.Y., Huang, Y., Tse, E., Sun, J., Bu, N., Chiou, S.H., Zhang, E.F, Hua, H.Y., Ma, L.Y., Huang, P., Ge, M.H., Cao F.L., Cheng X.D., Sun H.Z., Zhou J., Vasliou V., Xu P., Jin J., Bjorklund M., Zhu H.H., Hsu C.H., Naranmandura H.* "Hyperthermia selectively destabilizes ongoneic fusion proteins". Blood Cancer Discovery, 2(4), 388-401, doi: 10.1158/2643-3230.BCD-20-0188. 

  10. Wang H.B., Wang M.J., Xu X.H., Gao P., Xu Z.L., Zhang Q., Li H.Y., Yan A.X., Kao R.Y. -T., Sun H.Z.* “Multi-target mode of action of silver against Staphylococcus aureus endows it with capability to combat antibiotic resistance”. Nature Communications, 12, 3331, doi: 10.1038/s41467-021-23659-y.

  11. Yuan S.F., Yin X., Meng X.Z., Chan J.F.W., Ye Z.W., Riva L., Pache L., Chan C.C.Y., Lai P.M., Chan C.C.S., Poon V.K.M., Lee A. C.Y., Matsunaga N., Pu Y., Yuen C.K., Cao J.L., Liang R.H., Tang K.M., Sheng L., Du Y.S., Xu W., Lau C.Y., Sit K.Y., Au W.K., Wang R.M., Zhang Y.Y., Tang Y.D., Clausen T.M., Pihl J., Oh J., Sze K.H., Zhang A.J.X., Chu H., Kok K-H., Wang D., Cai X.H., Esko J.D., Hung I.F.N., Li R.A., Chen H.L., Sun H.Z., Jin D.Y., Sun R., Chanda S.K., Yuen K.Y.* (2021) “Clofazimine is a broad-spectrum coronavirus inhibitor that antagonizes SARS-CoV-2 replication in primary human cell culture and hamsters”. Nature, 593, 418-423. doi: 10.1038/s41586-021-03431-4. 

  12. Xu X.H.§, Wang H.B.§, Li H.Y., Sun H.Z.* (2021) “Dynamic and temporal transcriptomic analysis reveals ferroptosis-mediated anti-leukemia activity of S-dimethylarsino-glutathione: insights into novel therapeutic strategy” CCS Chemistry, 3, 1089-1100. doi: 10.31635/ccschem.021.202000685.

  13. Tse E.C.M.*, Sun H.Z.* (2020) Book review for “Transition Metals and Sulfur –A Strong Relationship for Life”, Metal Ions in Life Sciences, vol. 20, Zeitschrift für Naturforschung C, 76(5-6)c, 257-259, doi: 10.1515/znc-2020-0252.

  14. Zhou Y., Ip T.K.Y., Zhang Q., Li H.Y., Sun H.Z.* (2020) “Metal complexes as drugs and chemotherapeutic agents” in Comprehensive Coordination Chemistry III (Volume 9: “Applications of Coordination Chemistry”), 680-705, Elsevier. doi: 10.1016/B978-0-08-102688-5.00018-0.

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​2020

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  1. Wang H.B.*, Yang X.M., Wang M.J., Xu X.H., Hu M.L, Yan A.X., Hao Q., Li H.Y., Sun H.Z.* (2020) “Atomic differentiation of silver binding preference in protein targets: Escherichia coli malate dehydrogenase as a paradigm” Chemical Science, 11(43), 11714-11719. doi: 10.1039/D0SC04151C.

  2. Yuan S.F.§, Wang R.M.§, Chan J.F.W.§, Zhang A.J., Cheng T.F., Chik K.K.H., Ye Z.W., Wang S.Y., Lee A.C., Jin L.J., Li H.Y., Jin D.Y., Yuen K.Y.*, Sun H.Z.* (2020) “Metallodrug ranitidine bismuth citrate suppress SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters” Nature Microbiology, 5(11), 1439-1448. doi: 10.1038/s41564-020-00802-x.

  3. Sun H.Z.§*, Zhang Q.§, Wang R.M.§*, Wang H.B., Wong Y.T., Wang M.J., Hao Q., Yan A.X., Kao R.Y.T., Ho P.L., Li H.Y. (2020) “Resensitizing carbapenem- and colistin-resistant bacteria to antibiotics using auranofin” Nature Communications, 11(1), 5263, doi: 10.1038/s41467-020-18939-y.

  4. Wang R.M., Wang S.Y., Chan S., Zuo Z., Chan G.C.F., Li H.Y., Sun H.Z.* (2020) “Bismuth porphyrin antagonizes cisplatin-induced nephrotoxicity via inactivating caspase-dependent apoptotic pathway” iScience, 23(5), 101054. doi: 10.1016/j.isci.2020.101054.

  5. Tao X., Zhang Z.M., Zhang X., Li H.Y., Sun H.Z.*, Mao Z.W., Xia W.* (2020) “Structural insight into the substrate gating mechanism by Staphylococcus aureus aldehyde dehydrogenase” CCS Chemistry, 2(3), 946-954. doi: 10.31635/ccschem.020.202000219.

  6. Xu X.H., Wang H.B., Li H.Y., Sun H.Z.* (2020) “Metalloproteomic approaches for matching metals to proteins: The power of inductively coupled plasma mass spectrometry (ICP-MS)” Chemistry Letter, 49(6), 697-704. doi: 10.1246/cl.200155. (invited, featured on the front cover)

  7. Kanatzidis M., Sun H.Z., Dehnen S.* (2020) “Bismuth- the magic element” Inorganic Chemistry, 2020, 59(6) 3341-3343. doi: 10.1021/acs.inorgchem.0c00222. (editorial)

  8. Wang H.B., Zhou Y., Xu X.H., Li H.Y., Sun H.Z.* (2020) “Metalloproteomics in conjunction with other omics for uncovering the mechanism of action of metallodrugs: mechanism-driven new therapy development” Current Opinion in Chemical Biology, 55, 171-179. doi: 10.1016/j.cbpa.2020.02.006. (invited)

  9. Wang R.M., Li H.Y., Ip T.K.Y., Sun H.Z.* (2020) “Chapter 6 − Bismuth drugs as antimicrobial agents” Advances in Inorganic Chemistry, 75, 183-205. doi: 10.1016/bs.adioch.2019.10.011.

  10. Jiang N., Wang Y.L., Chan K.C., Sun H.Z.*, Li G.J.* (2020) “Additive manufactured graphene coating with synergistic photothermal and superhydrophobic effects for bactericidal applications” Global Challenges, 4(1), 1900054. doi: 10.1002/gch2.201900054.

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2019

  1. Koohi-Moghadam M., Wang H.B., Wang Y.C., Yang, X.M., Li H.Y., Wang J.W.*, Sun H.Z.* (2019) “Predicting disease-associated mutation of metal binding sites of a protein using a deep learning approach” Nature Machine Intelligence, 1(12), 561-567. doi: 10.1038/s42256-019-0119-z. (Highlighted as a ‘news&views’ entitled “DEEP LEARNING IN MEDICINE Predicting cracks in metalloproteins”, 1(12), 553-554)

  2. Xu Z.L., Wang P.C., Wang H.B., Hang Z., Au-Yeung H.Y., Hirayama T. Sun H.Z., Yan A.X. (2019) “Zinc excess leads to an increased cellular demand for iron and decreased tolerance to copper in Escherichia coli” Journal of Biological Chemistry, 294(45), 16978-16991. doi: 10.1074/jbc.RA119.010023.

  3. Xu, X.H., Wang H.B., Li, H.Y., Hu X.Q., Zhang Y., Guan X.Y., Toy P.H., Sun H.Z.* (2019) “S-dimethylarsino-glutathione (darinaparsin®) targets Histone H3.3, leading to TRAIL-induced apoptosis in leukemia cells” Chemical Communications, 55(87), 13120-13123. doi: 10.1039/C9CC07605K.

  4. Jiang N., Li H., Sun H.Z.* (2019) “Recognition of proteins by metal chelation-based fluorescent probes in cells” Frontiers in Chemistry, 7, 560. doi: 10.3389/fchem.2019.00560 (invited)

  5. Wang Y.C., Li H.Y., Sun H.Z.* (2019) “Metalloproteomics for unveiling the mechanism of action of metallodrugs and their candidates” Inorganic Chemistry, 58(20), 13673-13685. doi: 10.1021/acs.inorgchem.9b01199.  (featured in the Supplementary cover)

  6. Wang H.B., Wang M.J., Yang X.M., Xu X.H., Hu M.L., Yan A.X., Hao Q., Lobinski R., Li H.Y., Sun H.Z.* (2019) “Antimicrobial silver targets glyceraldehyde-3-phosphate dehydrogenase in E. coli”, Chemical Science, 10(30), 9193-7199.  doi: 10.1039/C9SC02032B.

  7. Wang Y.C., Han B.J., Xie Y.X., Wang H.B., Wang R.M., Xia W., Li H.Y., Sun H.Z.* (2019) “Combination of gallium(III) with acetate for combating antibiotic resistant Pseudomonas aeruginosai”, Chemical Science, 10(24), 6099-6106. doi: 10.1039/C9SC01480B. (ChemSci Pick of the Week  and HOT Article)

  8. Wang R.M., Li H.Y., Sun H.Z.* (2019) “Bismuth: environmental pollution and health effects” in Encyclopedia of Environmental Health, 2nd edition, edited by Nriagu J., Elsevier. 415-423. doi: 10.1016/B978-0-12-409548-9.11870-6. (invited contribution)

  9. Cheng T.F., Lai Y.T., Wang Y., Jiang N., Li H.Y., Sun H.Z.*, Jin L.J.* (2019) “Bismuth drugs tackle Porphyromonas gingivalis and attune cytokine response in human cells”, Metallomics, 11(7), 1207-1218. doi: 10.1039/c9mt00085b.

  10. Yang Y., Chang C.C., Lai Y.Z., Yang X.M., Sun H.Z.*, Li H.Y.* (2019) “Green fluorescent probe for imaging His6-tagged protein inside living cells” ACS Sensors, 4(5), 1190-1196. doi: 10.1021/acssensors.8b01128.

  11. Wang H.B., Yan A.X., Liu Z.G., Yang X.M., Xu Z.L., Wang M.J., Hu M.L., Wang Y.C., Wang R.M., Koohi-Moghadam M., Hu L.G., Xia W., Hao Q., Tang H.R., Wang Y.L., Li H.Y., Sun H.Z.* (2019) “Deciphering molecular mechanism of silver allows enhancing its antimicrobial efficacy”, PLOS Biology, 17(6): e3000292. doi: 10.1371/journal.pbio.3000292.

  12. Guo Y., Guan C.J., Wan H.Y., Zhang Z.G, Li H.Y., Sun H.Z., Xia W.* (2019) “Inactivation of NikR from Helicobacter pylori by a bismuth drug”, Journal of Inorganic Biochemistry, 196, 110685. doi: 10.1016/j.jinorgbio.2019.03.025.

  13. Zhang Z.M, Huang Q., Xu D., Tao X., Song G.B., Zheng P., Li H.Y., Sun H.Z., Xia W.* (2019) “The unique trimeric assembly of virulence factor HtrA from Helicobacter pylori via N-terminus domain-swapping”, Journal of Biological Chemistry, 294(20), 7990-8000. doi: 10.1074/jbc.RA119.007387. 

  14. Chan S., Wang R.M., Man K., Nicholls J., Li H.Y., Sun H.Z.*, Chan G.C.* (2019) “A novel synthetic compound, bismuth zinc citrate, could potentially reduce cisplatin-induced toxicity without compromising the anticancer effect through enhanced expression of antioxidant protein” Translational Oncology, 2019, 12(5), 788-799. doi: 10.1016/j.tranon.2019.02.003.

  15. Koohi-Moghadam M., Borad M., Tran N., Swanson K, Boardman L., Sun H.Z.*, Wang J.W.* (2019) “MetaMarker: a de novo pipeline for discovering novel metagenomic biomarkers” Bioinformatics, 35(19), 3812-3814. doi: 10.1093/bioinformatics/btz123.

  16. Li H.Y., Wang R.M., Sun H.Z.* (2019) “Systems approaches for unveiling the mechanism of action of bismuth drugs: new medicinal applications beyond Helicobacter pylori infection” Accounts of Chemical Research, 52(1), 216-227. doi: 10.1021/acs.accounts.8b00439.

  17. Cheng Y.H., Cheung Y.F., Tam T.S.C., Lok C.N., Sun H.Z., Ng K.M.* (2019) “Plasmonic metal nanoparticles as efficient mass tags for ion signal amplification and ultrasensitive detection of protein markers” Analytical Chimica Acta, 1055, 1-6. doi: 10.1016/j.aca.2018.12.057. (selected as “featured article”)

  18. Yang X.L., Liu X., Wu Q.Q., Lv X., Li B., Sun H.Z., Xu W.F., Liao X.L.* (2019) "Dopamine-assisted immobilization of peptide arginine-glycine-aspartic acid to enhance the cellular performances of MC3T3-E1 cells of carbon-carbon composites", Journal of Biomaterials Applications, 34(2), 284-296. doi: 10.1177/0885328219845962.

  19. Yang L.M., Xing S.Y., Sun H.Z., Miao C.L., Li M., Lv P.M., Wang Z.M., Yuan Z.H.* (2019) "Citric-acid-induced mesoporous SAPO-11 loaded with highly dispersed nickel for enhanced hydroisomerization of oleic acid to iso-alkanes", Fuel Processing Technology, 187, 52-62. doi: 10.1016/j.fuproc.2019.01.008.

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2018

  1. Prinz J., Koohi-Moghadam M., Sun H.Z., Kocher J.A., Wang J.W. (2018) “Novel neural network approach to predict drug-target interactions based on drug side effects and genome-wide association studies” Human Heredity, 83(2), 79-91. doi: 10.1159/000492574.

  2. Zhou Y., Wang H.B., Tse E., Li H.Y., Sun H.Z.* (2018) “Cell cycle-dependent uptake and cytotoxicity of arsenic-based drugs in single Leukemia cells” Analytical Chemistry, 90(17), 10465-10471. doi: 10.1021/acs.analchem.8b02444.

  3. Han B.J., Zhang Z., Xie Y.X, Hu X.Q., Wang H.B., Xia W., Wang Y.L, Li H.Y., Wang Y.C.*, Sun H.Z.* (2018) “Multi-omics and temporal dynamics profiling reveals disrupted central metabolism in Helicobacter pylori on bismuth treatment” Chemical Science, 9(38), 7488-7497. doi: 10.1039/C8SC01668B. (Chemical Science 2018 HOT article, highlighted in ChemistryWorld 2018, September issue, 44-45)

  4. Curtin J.P.*, Wang M.J., Cheng T.F., L.J. Jin, Sun H.Z. (2018) “The role of citrate, lactate and transferrin in determining titanium release from surgical devices into human serum” Journal of Biological Inorganic Chemistry, 23(3), 471-480. doi: 10.1007/s00775-018-1557-5.

  5. Wang R.M., Lai T.P., Gao P., Zhang H.M., Ho P.L, Ma G.X., Woo P.C.Y., Kao Y.T., Li H.Y., Sun H.Z. (2018) “Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors”, Nature Communications, 9(1), 439. doi: 10.1038/s41467-018-02828-6. 

  6. Yang X.M., Koohi-Moghadam M., Wang R.M., Chang Y.Y., Woo P.C.Y., Wang J.W., Li H.Y.*, Sun H.Z.* (2018) “Metallochaperone UreG serves as a new target for design of urease inhibitor: a novel strategy for development of antimicrobials” PLoS Biology, 16(1), e2003887. doi: 10.1371/journal.pbio.2003887.

  7. Jiang N., Cheng T.F., Wang M.J., Chan, G.C.F., Jin L.J., Li, H.Y., Sun H.Z.* (2018) “Tracking iron-associated proteomes in pathogens by a fluorescence approach”, Metallomics, 10(1), 77-82. doi: 10.1039/C7MT00275K.

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2017

  1. He X.J., Liao X.W., Li H Y., Xia W., Sun H.Z.* (2017) “Bismuth-induced inactivation of ferric uptake regulator from Helicobacter pylori” Inorganic Chemistry, 56(24), 15041-15048. doi: 10.1021/acs.inorgchem.7b02380.

  2. Liao X.W., Yang F., Li H.Y. Xia W.*, Sun H.Z.* (2017) “Targeting the thioredoxin reductase-thioredoxin system from Staphylococcus aureus by silver ions” Inorganic Chemistry, 56(24), 14823–14830. doi: 10.1021/acs.inorgchem.7b01904.

  3. Liao X.W., Yang F., Wang R.M., He X.J., Li H.Y., Kao R.Y.T., Xia, W.*, Sun H.Z.* (2017) “Identification of catabolite control protein A (ccpA) from Staphylococcus aureus as a target of silver ions” Chemical Science, 8(12), 8061-8066. doi: 10.1039/C7SC02251D.

  4. Wang Y.C., Hu L.G., Xu F., Quan Q., Lai Y.T., Xia W., Yang Y., Chang Y.Y., Yang X.M., Chai Z.F., Wang J.W., Chu I.K., Li H.Y., Sun H.Z.* (2017) “Integrative approach for analysis of proteome-wide response to bismuth drugs in Helicobacter pylori” Chemical Science, 8(6), 4626-4633. doi: 10.1039/C7SC00766C.

  5. Chang Y.Y., Cheng T.F., Yang X.M., Jin L.J., Sun H.Z.* (2017) “Functional disruption of peroxiredoxins by bismuth drugs attenuates Helicobacter pylori survival”, Journal of Biological Inorganic Chemistry, 22(5), 673-683. doi: 10.1007/s00775-017-1452-5.

  6. Zhou Y., Li H., Sun H.Z.* (2017) “Cytotoxicity of arsenic trioxide in single leukemia cells by time-resolved ICP-MS together with lanthanide-tags” Chemical Communications, 53(20), 2970-2973. doi: 10.1039/C7CC00143F.

  7. Lai Y.Z., Yang Y., Hu L.G., Cheng, T.F., Chang Y.Y., Koohi-Moghadam M., Wang Y.C., Xia J., Wang J.W., Li H.Y., Sun H.Z.* (2017) “Integration of fluorescent imaging with proteomics enables visualization and identification of endogenous metallo-proteomes in live cells” Metallomics, 9(1), 38-47. doi: 10.1039/C6MT00169F.

  8. Chao A., Jiang N., Yang Y., Li H.Y., Sun H.Z.* (2017) “A Ni-NTA-based red fluorescence probe for proteins labelling in live cells” Journal of Material Chemistry B, 2017, 5(6), 1166-1173. doi: 10.1039/C6TB02848A.

  9. Wang Y.C., Wang H.B., Li H.Y., Sun H.Z.* (2017) “Application of metallomics and metalloproteomics for understanding the molecular mechanisms of action of metal-based drugs” in “Essential and non-essential metals: carcinogenesis, prevention and chemotherapy” edited by Zelikoff J., Mudipalli A. Sr., Springer, Gewerbestrasse 11, 6330 Cham, Switzerland, 199-222. doi: 10.1007/978-3-319-55448-8_9.

  10. Chang Y.Y., Li H.Y., Sun H.Z.* (2017) “Chapter 9: Immobilized metal affinity chromatography (IMAC) for metalloproteomics and phosphoproteomics” in “Interactions of Inorganic and Organometallic Transition Metal Complexes with Biological Molecules and Living Cells” edited by Lo K.K.W., Elsevier, 329-353. doi: 10.1016/B978-0-12-803814-7.00009-5.

  11. Xia W., Li H.Y., Sun H.Z.* (2017) “Chapter 14: Nickel metallochaperones: structure, function and nickel-binding” in The Biochemistry of Nickel edited by Zamble D., Henryk K., Magdalena R-Z, The Royal Society of Chemistry, Cambridge, UK, 284-305. doi: 10.1039/9781788010580-00284.

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2016

  1. Cheng T.F., Li H.Y. Jin L.J., Sun H.Z.* (2016) “Exploration into the nickel ‘microcosmos’ in prokaryotes” Coordination Chemistry Reviews, 311, 24-37. doi: 10.1016/j.ccr.2015.12.007.

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2015

  1. Wang Y.C., Tsang C.Y., Xu F., Kong P.K., Hu L.G., Wang J.W., Chu IK, Li H.Y., Sun H.Z.* (2015) “Bio-coordination of bismuth in Helicobacter pylori revealed by immobilized metal affinity chromatography” Chemical Communications, 51(92), 16479-16482. doi: 10.1039/C5CC04958J. (featured on the outside back cover)

  2. Wang M.J., Lai T-P., Wang L., Zhang H.M., Yang N., Sadler P.J., Sun H.Z.* (2015) “Anion clamp” allows flexible protein to impose coordination geometry on metal ions” Chemical Communications, 51(37), 7867-7870. doi: 10.1039/C4CC09642H.

  3. Wang Y.C., Hu L.G., Yang X.M., Chang Y.Y, Hu X.Q., Li H.Y., Sun H.Z.* (2015) “On-line coupling of continuous-flow gel electrophoresis with inductively coupled plasma-mass spectrometry to quantitatively evaluate intracellular metal binding properties of metallochaperones HpHypA and HpHspA in E. coli cells” Metallomics, 7(10), 1399-1406. doi: 10.1039/c5mt00054h. (featured on the front cover of the October issue, 2015)

  4. Yang X.M., Li H.Y., Lai T.P., Sun H.Z.* (2015) “Complexation of Helicobacter pylori UreE-UreG facilitates nickel transfer and boosts GTPase activity of UreG” Journal of Biological Chemistry, 290(20), 12474-12485. doi: 10.1074/jbc.M114.632364. (selected as the Paper of the Week)

  5. Lai Y.Z., Chang Y.Y., Hu L.G., Yang Y., Chao A.L., Du Z.Y., Tanner J.A., Chye M.L., Qian C.M., Ng K.M., Li H.Y., Sun H.Z.* (2015) “Rapid labeling of intracellular His-tagged proteins in living cells” Proceedings of the National Academy of Sciences, USA, 112(10), 2948-2953. doi: 10.1073/pnas.1419598112.  (highlighted as a spotlight in Nat. Biotech. 2015, 33, 359, in the F1000Prime and local media). 

  6. Hong Y.F., Lai Y.T., Chan G.C.F., Sun H.Z.* (2015) “Glutathione and MRP transporter mediate a self-propelled disposal of bismuth in human cells” Proceedings of the National Academy of Sciences, USA, 112(11), 3211-3216. doi: 10.1073/pnas.1421002112. (highlighted in the issue, PNAS 112(11), 3717; as a commentary in PNAS 2015, 112(14), 4187-4188, as well as a spotlight in Chem Res Toxicology, 2015, 28, 829) 

  7. Tang H.M.V., Pan K.W., Kong K.Y.E., Hu L.G., Chan L.C., Siu K.L., Sun H.Z., Wong C.M., Jin D.Y. (2015) “Loss of APD1 in yeast confers hydroxyurea sensitivity suppressed by Yap1p transcription factor” Scientific Reports, 5, 7897, doi: 10.1038/srep07897.

  8. Chang Y.Y., Lai Y-T., Cheng T.F., Wang H.B., Yang Y., Sun H.Z.* (2015) “Selective binding of Hpnl-like protein to nickel, zinc and bismuth in vitro and in cells by FRET” Journal of Inorganic Biochemistry, 142(1), 8-14. doi: 10.1016/j.jinorgbio.2014.09.010.

  9. Wang Y.C., Wang H.B., Li H.Y. Sun H.Z.* (2015) “Metallomic and metalloproteomic strategies in elucidating the molecular mechanisms of metallodrugs” Dalton Transaction, 43(2), 437-447. doi: 10.1039/C4DT02814G.

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2014

  1. Qin F., Zhao H., Li G., Yang H., Li J., Wang R., Liu Y., Hu J., Sun H.Z., Chen R. (2014) "Size-tunable fabrication of multifunctional Bi2O3 porous nanospheres for photocatalysis, bacteria inactivation and template-synthesis" Nanoscale, 6 (10), 5402-5409. doi: 10.1039/C3NR06870F.

  2. Xia W., Li H.Y., Sun H.Z.* (2014) "Functional disruption of HypB, a GTPase of Helicobacter pylori, by bismuth"Chemical Communications, 50 (13), 1611-1614. doi: 10.1039/C3CC47644H.

  3. Cun S.J., Sun H.Z.* (2014) "Urease inactivation by an unusual GroES chaperonin"Science China Chemistry, 57 (6), 842-848. doi: 10.1007/s11426-014-5088-9.

  4. Li H.Y. *, Sun H.Z.* (2014) "In-cell NMR: An emerging approach for monitoring metal-related events in living cells" Metallomics, 6 (1), 69-76. doi: 10.1039/C3MT00224A.

  5. Cheng T.F., Sun H.Z.* (2014) "Chapter 25 - Antimony and bismuth" Binding, Transport and Storage of Metal Ions in Biological Cells, 2014-January (2), 768-799. doi: 10.1039/9781849739979-00768.

  6. Yang X.M., Li H.Y., Cheng T.F., Xia W., Lai Y.-T., Sun H.Z.* (2014) "Nickel translocation between metallochaperones HypA and UreE in Helicobacter pylori" Metallomics, 6 (9), 1731-1736. doi: 10.1039/c4mt00134f.

  7. Xie S., Lu Y., Jakoncic J., Sun H.Z., Xia J., Qian C.M. (2014) "Structure of RPA32 bound to the N-terminus of SMARCAL1 redefines the binding interface between RPA32 and its interacting proteins" FEBS Journal, 281 (15), 3382-3396. doi: 10.1111/febs.12867.

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2013

  1. Chen W.J., Wang H.F., Ye D.R., Lin H., Sun H.Z., Zhong W.Q. (2013) “Binding of oxo-Cu2 clusters to ferric ion-binding protein A from Neisseria gonorrhoeae: a structural insight” Metallomics, 5(10),  1430-1439. doi: 10.1039/C3MT00091E.

  2. Li G., Qin F., Wang R., Xiao S, Sun H.Z., Chen R. (2013) “BiOX (X=Cl, Br, I) nanostructures: mannitol-mediated microwave synthesis, visible light photocatalytic performance, and Cr(VI) removal capacity” Journal of Colloid and Interface Science, 409, 43-51. doi: 10.1016/j.jcis.2013.07.068.

  3. Cun S.J., Lai Y.Z., Chang Y.Y., Sun H.Z.* (2013) “Structure-oriented bioinformatic approach exploring histidine-rich clusters in proteins” Metallomics, 5(7), 904-912. doi: 10.1039/c3mt00026e.

  4. Cheng T.F., Li H.Y., Yang X.M., Xia W., Sun H.Z.* (2013) “Interactions of SlyD with HypB of Helicobacter pylori facilitates nickel trafficking” Metallomics, 5(7), 804-807. doi: 10.1039/C3MT00014A.

  5. Sun H.Z. (2013) “Metallomics in China” Metallomics, 5(7), 782-783. doi: 10.1039/C3MT90024J.

  6. Du X.B., Wang X.H., Li H.Y., Sun H.Z.* (2013) “Kinetics and thermodynamics of metal binding to the N-terminus of human copper transporter, hCTR1” Chemical Communications, 49(80), 4134-4136. doi: 10.1039/C3CC45360J.

  7. Hu L.G., Cheng T.F., He B., Li L., Wang Y.C., Lai Y.T., Jiang G.B., Sun H.Z.* (2013) “Identification of metal-associated proteins in cells by using continuous-flow gel electrophoresis and inductively coupled plasma mass spectrometry” Angewandte Chemie International Edition, 52(18), 4916-4920. doi: 10.1002/anie.201300794.

  8. Yang X.M., Xu D.C., Cheng T.F., Xi Z.Y., Zhao L.H., Liu Y.Z.*, Sun H.Z.* (2013) “Recent progress of copper and nickel chaperones” Progress in Chemistry, 25(4), 495-510. 

  9. Wang X.H., Sun H.Z.* (2013) “3.39- Metal complexes in the treatment of tropical diseases: malaria, trypanosomiasis and leishmaniasis” Comprehensive Inorganic Chemistry II (2nd edition), Volume 3- Bioinorganic Fundamentals and Applications: Metals in Natural Living Systems and Metals in Toxicology and Medicine, 975-986, Elsevier, 2013. doi: 10.1016/B978-0-08-097774-4.00339-9. (invited)

  10. Xiong J.Y., Cheng G., Qiu F., Wang R.M., Sun H.Z., Chen R. (2013) “Tunable BiOCl hierarchical nanostructures for high-efficient photocatalysis under visible light irradiation” Chemical Engineering Journal, 220, 228-236. doi: 10.1016/j.cej.2013.01.033.

  11. Hu L.G.*, Wang Y.C., He B., Jiang G.B., Sun H.Z.* (2013) “Metallomics in environmental and health related research: current status and perspectives” Chinese Science Bulletin, 58(2), 169-176. doi: 10.1007/s11434-012-5496-1.

  12. Cheng T.F., Xia W., Wang P.W., Huang F.J. Wang J.W., Sun H.Z.* (2013) "Histidine-rich proteins in prokaryotes: metal homeostasis and environmental habitat-related occurrence" Metallomics, 5, 1423-1429. doi: 10.1039/C3MT00059A.

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2012

  1. Yang N., Zhang H.M., Hao Q., Sun H.Z.* (2012) “Iron and bismuth bound human serum transferrin reveals a partially-opened conformation in the N-lobe” Scientific Reports, 2, 999; doi: 10.1038/srep00999.

  2. Wang X.H., Li H.Y., Du X.B., Harris J., Guo Z.J., Sun H.Z.* (2012) “Activation of carboplatin and nedaplatin by the N-terminus of human copper transporter 1 (hCTR1)” Chemical Science, 3(11), 3206-3215. doi: 10.1039/C2SC20738A.

  3. Xia W., Li H.Y., Yang X.M., Wong K.B., Sun H.Z.* (2012) “Metallo-GTPase HypB from Helicobacter pylori and its interaction with nickel chaperone protein HypA” Journal of Biological Chemistry, 287(9), 6753-6763. doi: 10.1074/jbc.M111.287581.                         

  4. Cheng T.F., Li H.Y., Xia W., Sun H.Z.* (2012) “Multifaceted SlyD from Helicobacter pylori: implication in [NiFe] hydrogenase maturation” Journal of Biological Inorganic Chemistry, 17(3), 331-343. doi: 10.1007/s00775-011-0855-y.                                                      

  5. Qin F., Li G.F., Xiao H., Lu Z., Sun H.Z., Chen R. (2012) “Large-scale synthesis of bismuth hollow nanospheres for highly efficient Cr(VI) removal” Dalton Transactions, 41(37), 11263-11266. doi : 10.1039/C2DT31021J.

  6. Qin F., Li G.F., Wang R.M., Wu J.L., Sun H.Z., Chen R. (2012) “Template-free fabrication of Bi2O3 and (BiO)2CO3 nanotubes and their application in water treatment” Chemistry, a European Journal, 18(51), 16491-16497. doi: 10.1002/chem.201201989.

  7. Du X.B., Wang X.H., Li H.Y., Sun H.Z.* (2012) “Comparison between copper and cisplatin transport mediated by human copper transporter 1 (hCtr1)” Metallomics, 4(7), 679 -685. doi: 10.1039/C2MT20021J.

  8. Li G.F., Qin F., Yang H., Lu Z., Sun H.Z., Chen R. (2012) “Facile microwave synthesis of 3D flowerlike BiOBr nanostructures and their excellent CrVI removal capacity” European Journal of Inorganic Chemistry, 2508-2513. doi: 10.1002/ejic.201101427.

  9. Xu Z.H., Jin J., Siu L.K.S., Yao H., Sze J., Sun H.Z., Kung H.F., Poon W.S., Ng S.S.M., Lin M.C. (2012) “Folic acid conjugated mPEG-PEI600 as an efficient non-viral vector for targeted nucleic acid delivery” International Journal of Pharmaceutics, 426(1-2), 182-192. doi: 10.1016/j.ijpharm.2012.01.009.

  10. Shan Y., Pan Q., Liu J., Huang F.J., Sun H.Z., Nishino K., Yan A. (2012) “Covalently linking the Escherichia coli global anaerobic regulator FNR in tandem allows it to function as an oxygen stable dimer” Biochemical and Biophysical Research Communications, 419(1), 43-48. doi: 10.1016/j.bbrc.2012.01.121.

  11. Li H.Y., Sun H.Z.* (2012) “Recent advances in bioinorganic chemistry of bismuth”. Current Opinion in Chemical Biology, 16(1-2), 74-83. doi: 10.1016/j.cbpa.2012.01.006.

  12. Tsang C.N., Bianga J., Sun H.Z., Szpunar  J., Lobinski R. (2012) “Probing of bismuth antiulcer drug targets in H. pylori by laser ablation- inductively coupled plasma mass spectrometry”  Metallomics, 4(3), 277-283. doi: 10.1039/C2MT00169A.

  13. Li H.Y., Sun H.Z. (2012) “NMR studies of metalloproteins” Topics in Current Chemistry (NMR of proteins and small biomolecules), 326, 69-98. doi: 10.1007/128_2011_214.

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2011

  1. Fong Y.H., Wong H.C., Chuck C.P., Chen Y.W., Sun H.Z., Wong K.B. (2011) “Assembly of the preactivation complex for urease maturation in Helicobacter pylori: crystal structure of the UreF/UreH complex” Journal of Biological Chemistry, 286(50), 43241-43249. doi: 10.1074/jbc.M111.296830. (Paper of the Week)  

  2. Li G., Ding Y., Zhang Y., Lu Z., Sun H.Z., Chen R. (2011) “Microwave synthesis of BiPO4 nanostructures and their morphology-dependent photocatalytic performances” Journal of Colloid and Interface Science, 363 (2), 497-503. doi: 10.1016/j.jcis.2011.07.090.

  3. Ge R.G., Sun X.S., Wang D. X., Zhou Q.L., Sun H.Z. (2011) “Histidine-rich protein Hpn from Helicobacter pylori forms amyloid-like fibrils in vitro and inhibits the proliferation of gastric epithelial AGS cells” Biochimica et Biophysica Acta - Molecular Cell Research, 1813(8), 1422-1427. doi: 10.1016/j.bbamcr.2011.04.005.

  4. Zeng Y.B., Yang N., Sun H.Z.* (2011) “Metal-binding properties of histidine-rich protein, Hpn-like” Chemistry, a European Journal, 17(21), 5852-5860. doi: 10.1002/chem.201100279.  (Inside Cover)

  5. Tsang C.N., Ho K.S., Sun H.Z.*, Chan W.T.* (2011) “Tracking bismuth drug uptake in single Helicobacter pylori cells” Journal of the American Chemical Society, 133(19), 7355-7357. doi: 10.1021/ja2013278.

  6. Wang X.H., Du X.B., Li H.Y., Chan D.S.B., Sun H.Z.* (2011) “The effect of the extracellular domain of human copper transporter (hCTR1) on cisplatin activation” Angewandte Chemie International Edition, 50(12), 2706-2711. doi: 10.1002/anie.201006739. (Frontispiece)

  7. Yang N., Sun H.Z.* (2011) “Bismuth: environmental pollution and health effects” in Nriagu JO (ed.) Encyclopedia of Environmental Health, Volume 1, 414-420 Burlington:  Elsevier doi:  10.1016/B978-0-444-52272-6.00374-3. (invited).

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2010

  1. Yang N., An Y., Cai J.W., Hu L.H., Zeng Y.B., Mao Z.W., Chen G.H., Sun H.Z.* (2010) “Polymeric architectures of bismuth citrate based on dimeric building blocks” Science in China- Chemistry, 53(10), 2152-2158. doi: 10.1007/s11426-010-4113-x.

  2. Sun X.S, Ge R.G., Zhang D.M., Sun H.Z., He Q.Y. (2010). “Iron-containing lipoprotein SiaA in SiaABC, the primary heme transporter of Streptococcus pyogenes” Journal of Biological Inorganic Chemistry, 15(8), 1265-1273. doi: 10.1007/s00775-010-0684-4.

  3. Sun H.Z.*, Chai Z.F. (2010) “Metallomics: an integrated science for metals in biology and medicine” Annual Reports on the Progress of Chemistry, Section A: Inorganic Chemistry, 106, 20-38. doi: 10.1039/B920672H. (Featured on the cover of 2010 issue)

  4. Cun S.J., Sun H.Z.* (2010) “A zinc-binding site by negative selection induces metallodrug susceptibility of an essential chaperonin”, Proceedings of the National Academy of Sciences, USA, 107(11), 4943-4948. doi: 10.1073/pnas.0913970107.

  5. Tian Y., Hou X., Wen L., Guo W., Song Y., Sun H.Z., Wang Y., Jiang L., Zhu D. (2010) “A biomimetic zinc activated ion channel” Chemical Communications, 46(10), 1682-1684. doi: 10.1039/B918006K.

  6. Ge R.G., Chu I.K., Sun H.Z.* (2010) “Chapter 9 - Nuclear-based metallomics in metal-based drugs” in Advanced nuclear analytical techniques for metallomics and metalloproteomics (Edited by C.Y. Chen, Z.F. Chai, YX Gao), Royal Society of Chemistry, 265-298. doi: 10.1039/9781847559913-00265.

  7. Chen R., Cheng G., Man S.H., Wu J.L., Lu Z., Che C.-M., Sun H.Z. (2010) “Bismuth subcarbonate nanoparticles fabricated by water-in-oil micromulsion-assisted hydrothermal process exhibit anti-Helicobacter pylori properties” Materials Research Bulletin, 45(5), 654-658. doi: j.materresbull.2009.12.035.

  8. Li H.Y.*, Sze K.H., Fung K.L., Sun H.Z.* (2010)“Validation of inter-helical orientation of the sterile-alpha-motif domain of the deleted in liver cancer 2 (DLC2-SAM) by 15N-1H residual dipolar couplings” Chinese Journal of Magnetic Resonance, 27(4), 585-596. (invited)

  9. Lam M.P.Y., Siu S.O., Lau E., Mao X.L., Sun H.Z., Chiu P.C.N., Yeung W.S.B., Cox D.M., Chu I.K. (2010) "Online coupling of reverse-phase and hydrophilic interaction liquid chromatography for protein and glycoprotein characterization" Analytical and Bioanalytical  Chemistry, 398(2), 791-804. doi: 10.1007/s00216-010-3991-2.

  10. Sun H.Z., Lam K.M., Fung Y.S. (2010) "A new capillary electrophoresis buffer for determining organic and inorganic anions in electroplating bath with surfactant additives" Journal of Chromatography. A, 1217(19), 3244-3250. doi: 10.1016/j.chroma.2010.01.011.

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2009

  1. Wu Z.Y., Liu Q., Liang X., Yang X., Wang N.Y., Wang X.H., Sun H.Z., Lu Y., Guo Z.J. (2009) “Reactivity of platinum-based antitumor drugs towards a Met- and His-rich 20mer peptide corresponding to the N-terminal domain of human copper transporter 1” Journal of Biological Inorganic Chemistry, 14(8), 1313-1323. doi: 10.1007/s00775-009-0576-7.

  2. Ding Z.C., Teng X.C., Zheng Q., Ni F.Y., Cai B., Wang Y., Zhou G.M., Sun H.Z., Tan X.S., Huang Z.X. (2009) “Important roles of the conserved linker-KKS in human neuronal growth inhibitory factor” BioMetals, 22(5), 817-826. doi: 10.1007/s10534-009-9228-1.

  3. Sun X.S., Ge R.G., Chiu J.F., Sun H.Z.*, He, Q.Y.* (2009) “Iron depletion decreases proliferation and induces apoptosis in a human colonic adenocarcinoma cell line, Caco2” Journal of Inorganic Biochemistry, 103(7), 1074-1081. doi: 10.1016/j.jinorgbio.2009.05.004 .

  4. Xia W., Li H.Y., Sze K.H., Sun H.Z.* (2009) “Structure of a nickel chaperone, HypA from Helicobacter pylori reveals two distinct metal binding sites” Journal of the American Chemical Society, 131(29), 10031-10040. doi: 10.1021/ja900543y.

  5. Sun X.S., Baker H.M., Ge R.G., Sun H.Z., He Q.Y., Baker E.N. (2009) “Crystal structure and metal binding properties of the lipoprotein MtsA, responsible for iron transport in Streptococcus pyogenes” Biochemistry, 48(26), 6168-6190. doi: 10.1021/bi900552c.

  6. Cai B., Ding Z.C., Zhang Q., Ni F.Y., Wang H., Zheng Q., Wang Y., Zhou G.M., Wang K.M., Sun H.Z., Wu H.M., Huang Z.X. (2009) “The structural and biological significance of the EAAEAE insert in the α-domain of the human neuron growth inhibitory factor” FEBS Journal, 276(13), 3547-3558. doi: 10.1111/j.1742-4658.2009.07075.x.

  7. Sun X.S., Tsang C.N., Sun H.Z.* (2009) “Identification and characterization of metallodrugs binding proteins by (metallo)proteomics” Metallomics, 1(1), 25-31. doi: 10.1039/B813121J. (Featured on the cover of the January issue, 2009)                                                                       

  8. He J., Hu P., Wang Y.J., Tong M.-L., Sun H.Z., Mao Z.W.* Ji L.-N. (2008) “Double-strand DNA cleavage by copper complexes of 2,2-dipyridyl with guanidinium/ammonium pendants” Dalton Transactions, (24), 3207-3214. doi: 10.1039/B801549J.

  9. He J., Sun J., Mao Z.W., Ji L.N., Sun H.Z. (2009) “Phosphodiester hydrolysis and specific DNA binding and cleavage promoted by guanidinium-functionalized zinc complexes” Journal of Inorganic Biochemistry, 103(5), 851-858. doi: 10.1016/j.jinorgbio.2009.02.010.

  10. Zhou Y.H., Zhao M., Sun H.Z., Mao Z.W., Ji L.N. (2009) “Effect of cyclodextrin dimers with bipyridyl and biphenyl linking groups on carboxyl ester hydrolysis catalyzed by zinc complex” Journal of Molecular Catalysis A: Chemical, 308 (1-2), 61-67. doi: 10.1016/j.molcata.2009.03.026.

  11. Ge R.G., Sun H.Z. (2009) "Metallomics: An integrated biometal science" Science in China Series B Chemistry, 52(12), 2055-2070. doi: 10.1039/B308213J.

  12. Huang J.D., Sun H.Z., Tanner J.A., Watt R.M. (2009) "Determination of the functions of the putatuve metal-binding domain of the SCV helicase" Hong Kong Medical Journal, 15(Suppl 6), 15-16.

​

2008

  1. Zeng Y.B., Zhang D.M., Li H.Y., Sun H.Z.* (2008) “Binding of Ni2+ to a histidine- and glutamine-rich protein, Hpn-like (Hpnl)” Journal of Biological Inorganic Chemistry, 13(7), 1121-1131. doi: 10.1007/s00775-008-0397-0.

  2. Cun S.J., Li H.Y., Ge R.G., Lin M.C.M., Sun H.Z.* (2008) “A histidine- and cysteine-rich metal binding domain at the C-terminus of heat-shock protein A from Helicobacter pylori: implication for nickel homeostasis and bismuth susceptibility” Journal of Biological Chemistry, 283, 15142-15151. doi: 10.1074/jbc.M800591200.

  3. Sun X.S., Ge R.G., Chiu J.F., Zu Y.B., Sun H.Z.*, He Q.-Y.* (2008) “Lipoprotein MtsA of MtsABC in Streptococus progenes primarily binds ferrous ion with bicarbonate as a synergistic anion” FEBS Letter, 582(9), 1351-1354. doi: 10.1016/j.febslet.2008.03.020.

  4. Li H.Y., Gu J.D., Sun H.Z.* (2008) “Structure, topology and assembly of a 32-mer peptide corresponding to the loop 3 and transmembrane domain 4 of divalent metal transporter (DMT1) in membrane-mimetic environments” Journal of Inorganic Biochemistry, 102(5-6), 1257-1266. doi: 10.1016/j.jinorgbio.2007.12.019.

  5. Wang H., Li H.Y., Cai B., Huang Z.X., Sun H.Z.* (2008) “The effect of nitric oxide (NO) on metal release from human metallothionein-3 (MT-3): gradual unfolding of the protein” Journal of Biological Inorganic Chemistry, 13(3), 411-419. doi: 10.1007/s00775-007-0331-x.

  6. Sun X.S., Ge R.G., Chiu J.F., Sun H.Z.*, He Q.Y.* (2008) “Identification of proteins related to nickel homeostasis in Helicobater pylori by immobilized metal affinity chromatography and two-dimensional gel electrophoresis” Metal-Based Drug, 2008, 289490. doi: 10.1155/2008/289490.

  7. Huang J.D., Zheng B.J., Sun H.Z. (2008) “Helicases as antiviral drug targets” Hong Kong Medical Journal, 14 Suppl 4, 36-38.

  8. Ding Z.C., Zheng Q., Cai B., Ni F.Y., Yu W.H., Teng X.C., Gao Y., Liu F., Chen D., Wang Y., Wu H.M., Sun H.Z., Zhang M.J., Tan X.S., Huang Z.X. (2008) “Study on structure-property-reactivity-function relationship of human neuronal growth inhibitory factor (hGIF)” Journal of Inorganic Biochemistry, 102 (11), 1965-1972. doi: 10.1016/j.jinorgbio.2008.07.007.

  9. He J., Hu P., Wang Y.-J., Tong M.-L., Sun H.Z., Mao Z.-W., Ji L.-N. (2008) "Double-strand DNA cleavage by copper complexes of 2,2'-dipyridyl with guanidinium/ammonium pendants" Dalton Transactions, 3207-3214. doi: 10.1039/B801549J.

​

2007

  1. Ding Z.C., Zheng Q, Can B., Yu W.H., Teng X.C., Wang Y., Zhou G.M., Wu H.M., Sun H.Z., Zhang M.J., Huang Z.X. (2007) “Effect of α-domain substitution on the structure, property and function of human neuronal growth inhibitory factor” Journal of Biological Inorganic Chemistry, 12(8), 1173-1179. doi: 10.1007/s00775-007-0287-x.

  2. Ge R.G., Sun H.Z.* (2007) “Bioinorganic chemistry of bismuth and antimony: target sites for metallodrugs” Accounts of Chemical Research, 40(4), 267-274. doi: 10.1021/ar600001b.

  3. Li H.Y., Fung K.L., Jin D.Y., Chung S.S.M., Ching Y.P., Ng I.O., Sze K.H., Ko B.C.B.*, Sun H.Z.* (2007) “Solution structures, dynamics and lipid-binding of SAM domain from the deleted in liver cancer 2 (DLC2): a monomeric structure with membrane-binding properties” PROTEINS: Structure, Function, and Bioinformatics, 67(4), 1154-1166. doi: 10.1002/prot.21361.

  4. Ni F.Y., Cai B.,  Ding Z.C., Zheng F., Zhang M.J., Wu H.M., Sun H.Z., Huang Z.X. (2007) “Structural prediction of the β-domain of metallothionein-3 by molecular dynamics simulation” PROTEINS: Structure, Function, and Bioinformatics,  68(1), 255-266. doi: 10.1002/prot.21404.

  5. Wong I.L.K., Chan K.F., Burkett B.A., Zhao Y., Chai Y., Sun H.Z., Chan T.H., Chow L.M.C. (2007) “Flavonoid dimers as bivalent modulators for pentamidine and sodium stiboglucanate resistance in Leishmania” Antimicrobial Agents and Chemotherapy, 51(3), 930-940. doi: 10.1128/AAC.00998-06.

  6. Yang N., Sun H.Z.* (2007) “Biocoordination chemistry of bismuth: recent advances” Coordination Chemistry Reviews, 251(17-20), 2354-2366. doi: 10.1016/j.ccr.2007.03.003.

  7. Yang N., Tanner J.A., Zheng B.J., Watt R.M., He M.L., Lu L.Y., Jiang J.-Q., Shum K.-T., Lin Y.-P., Lin M.C.M., Kung H.F., Sun H.Z.*, Huang J.D.* (2007) “Bismuth complexes inhibit the SARS coronavirus” Angewandte Chemie International Edition 46(34), 6464-6468. doi: 10.1002/anie.200701021.

  8. Yang N., Tanner J.A., Wang Z., Huang J.D., Zheng B.J., Zhu N., Sun H.Z.* (2007) “Inhibition of SARS coronavirus helicase by bismuth complexes” Chemical Communications, (42), 4413-4415. doi: 10.1039/B709515E.

  9. Yang Z., Wang X., Diao H., Zhang J., Li H.Y., Sun H.Z., Guo Z.J. (2007) “Encapsulation of platinum anticancer drugs by apoferritin” Chemical Communications, (33), 3453-3455. doi: 10.1039/B705326F. (Featured on the cover of the issue on September 7, 2007)

  10. Ge R.G., Sun X.S., Gu Q., Watt R.M., Wong B.C.Y., Xia H.H.X., Huang J.D., He Q.Y.*, Sun, H.Z.* (2007) “A proteomic approach for the identification of bismuth-binding proteins in Helicobacter pylori” Journal of Biological Inorganic Chemistry, 12(6), 831-824. doi: 10.1007/s00775-007-0237-7.

  11. Lok C.-N., Ho C.-M., Chen R., He Q.-Y., Yu W.-Y., Sun H.Z., Tam P.K.-H., Chiu J.-F., Che C.M. (2007) “Silver nanoparticles: partial oxidation and antibacterial activities” Journal of Biological Inorganic Chemistry, 12(4), 527-534. doi: 10.1007/s00775-007-0208-z.

  12. Zhou Y.H., Fu H., Zhao W.X., Su C.Y., Sun H.Z., Ji L.N., Mao Z.W. (2007) “An effective metallohydrolase model with supramolecular environment: structures, properties and activities” Chemistry, a European Journal, 13(8), 2402-2409. doi: 10.1002/chem.200601302.

  13. Zhou Y.H., Fu H., Zhao W.X., Chen W.L., Su C.Y., Sun H.Z., Ji L.N., Mao Z.W. (2007) “Synthesis, structure, and activity of supramolecular mimics for the active site and arg141 residue of copper, zinc-superoxide dismutase” Inorganic Chemistry,  46(3), 734-739. doi: 10.1021/ic061541d.

  14. An Y., Lin Y.Y., Wang H., Sun H.Z., Tong M.L., Ji L.N., Mao Z.W. (2007) “Cleavage of double-strand DNA by zinc complexes of dicationic 2,2'-dipyridyl derivatives” Journal of Chemical Society, Dalton Transactions, (12), 1250-1254. doi: 10.1039/B616754C.

​

2006

  1. Ding Z.C., Teng X.C., Cai B., Wang H., Zheng Q., Wang Y., Zhou G.M., Zhang M.J., Wu H.M., Sun H.Z., Huang Z.X. (2006) “Mutation at Glu23eliminates the neuron growth inhibitory activity of human metallothionein-3” Biochemical and Biophysical Research Communications, 349(2), 674-682. doi: 10.1016/j.bbrc.2006.08.090.

  2. Ge R.G., Zhang Y., Sun X.S., Watt R.M., He Q.-Y., Huang J.D., Wilcox D.E., Sun H.Z.* (2006) “Thermodynamic and kinetic aspects of metal binding to the histidine-rich protein, Hpn” Journal of the American Chemical Society, 128(35), 11330-11331. doi: 10.1021/ja062589t.

  3. Lok C.-N., Ho C.-M., Chen R., He Q.-Y., Yu W.-Y., Sun H.Z., Tam P.K.-H., Chiu J.-F., Che C.-M. (2006) “Proteomic analysis of the mode of antibacterial action of silver nanoparticles” Journal of Proteome Research, 5(4), 916-924. doi: 10.1021/pr0504079.

  4. Chen R., So M.H., Yang J., Deng F., Che C.-M., Sun H.Z.* (2006) “Fabrication of bismuth subcarbonate nanotube arrays from bismuth citrate” Chemical Communications, (21), 2265-2267. doi: 10.1039/B601764A.

  5. Cai B., Zheng Q., Teng X.C., Chen D., Wang Y., Wang K.Q., Zhou G.M., Xie Y., Zhang M.J., Sun H.Z.*, Huang Z.H. * (2006) “The Role of Thr5 in human neuron growth inhibitory factor” Journal of Biological Inorganic Chemistry, 11(4), 476-482. doi: 10.1007/s00775-006-0097-6.

  6. Xue R., Wang S., Wang C.Y., Zhu T., Li, F., Sun H.Z. “HFIP-induced structures and assembly of the peptides from the transmembrane domain 4 of membrane protein, Nramp1” (2006) Biopolymers, 84(3), 329–339. doi: 10.1002/bip.20478.

  7. Wang H., Zheng Q., Cai B., Li H.Y., Sze K.H., Huang Z.X., Wu H.M., Sun H.Z.* (2006) “Solution structure and dynamics of human metallothionein-3 (MT-3)” FEBS Letters, 580(3), 795-800. doi: 10.1016/j.febslet.2005.12.099.

  8. Zhang L., Mulrooney S.B.,  Leung F.K., Zeng Y.B., Ko B.C.B., Hausinger R.P.*, Sun H.Z.* (2006) “Inhibition of urease by bismuth(III): implications for the mechanism of action of bismuth drugs” BioMetals, 19(5), 503-511. doi: 10.1007/s10534-005-5449-0.

  9. Ge R.G., Watt R.M., Sun X., Tanner J.A., He Q.Y., Huang J.D.*, Sun H.Z.* (2006) “Expression and characterization of a histidine-rich protein: potential for Ni2+ storage in Helicobacter pylori” Biochemical Journal 393(Pt 1), 285-293. doi: 10.1042/BJ20051160.

​

2005

  1. Chai Y., Yan S.C., Wong I.L.K., Chow L.M.C., Sun H.Z.* (2005) “Complexation of antimony (SbV) with 5´-GMP and 5´-GDP-mannose: formation of both mono- and bis-adducts” Journal of Inorganic Biochemistry, 99(12), 2257-2263. doi: 10.1016/j.jinorgbio.2005.08.015.

  2. Zheng B.J., Guan Y., He M.L., Sun H.Z., Du L., Zheng Y., Wong K.L., Chen H., Chen Y., Lu L., Tanner J.A., Watt R.M., Niccolai N., Bernini A., Spiga O., Woo P.C., Kung H.F., Yuen K.Y., Huang J.D. (2005) “Synthetic peptides outside the spike protein heptad repeat regions as potent inhibitors of SARS-associated coronavirus” Antiviral Therapy, 10(3), 393-403.

  3. Chen R., So M.H., Che C.-M., Sun H.Z.* (2005) “Controlled synthesis of high crystalline bismuth sulfide nanorods: using bismuth citrate as a precursor” Journal of Materials Chemistry, 15(42), 4540-4545. doi: 10.1039/B510299E.

  4. Yang P.Y., Gao H.Y., Cai J.Y., Chiu J.F., Sun H.Z., He Q.-Y. (2005) “The stepwise process of chromium-induced DNA breakage: characterization by electrochemistry, atomic force microscopy and DNA electrophoresis” Chemical Research in Toxicology, 18(10), 1563-1566. doi: 10.1021/tx050134w.

  5. Li H.Y., Li F., Kwan M.F., He Q.-Y., Sun H.Z.* (2005) “NMR structures and orientation of the fourth transmembrane domain of the rat divalent metal transporter (DMT1) with G185D mutation in SDS micelles” Biopolymers, 77(4), 173-183. doi: 10.1002/bip.20204.

  6. Li F., Li H.Y., Kwan M.F., Hu L.H., Chen G.H., He Q.-Y., Sun H.Z.* (2005) “Structure, assembly and topology of G185R mutant of the transmembrane domain4 of divalent metal transporter” Journal of the American Chemical Society, 127(5), 1414-1423. doi: 10.1021/ja047148t.

  7. Yan S.C., Jin L., Sun H.Z.* (2005) “51Sb- antimony in medicine” in ‘Metallotherapeutics Drugs and Metal-Based Diagnostic Agents: The Use of Metals in Medicine’ (eds. Tiekink E.R.T., Gielen M.), John Wiley & Sons, 441-461. doi: 10.1002/0470864052.ch23.

  8. Yang P.Y., Sun X. S., Chiu J.F., Sun H.Z., He Q.Y.* (2005) “Transferrin-mediated gold nanoparticle cellular uptake”. Bioconjugate Chemistry, 16(3), 494-496. doi: 10.1021/bc049775d. (Most-cited Article in 2005 in Bioconjugate Chemistry)

  9. Teng X.C., Zheng Q., Cai B., Ni F.Y., Xie Y., Sun H.Z., Zhang M.J., Huang Z.X. (2005) "An Insight of S-Nitrosylation of Human GIF" Chinese Journal of Chemistry, 23(11), 1545-1551. doi: 10.1002/cjoc.200591545.

​

2004

  1. Sun R.W., Yu W.Y., Sun H.Z., Che C.M. (2004) “In vitro inhibition of human immunodeficiency virus type-1 (HIV-1) reverse transcriptase by gold(III) porphyrins” ChemBioChem, 5(9), 1293-1298. doi: 10.1002/cbic.200300773.

  2. Sun X., Sun H.Z., Ge R., Richter M., Woodworth R.C., Mason A.B., He Q.Y. (2004) “The low pKa value of iron-binding ligand tyr188 and its implication in iron release and anion binding of human transferrin”  FEBS Letters, 573(1-3), 181-185. doi: 10.1016/j.febslet.2004.07.076.

  3. Li H.Y., Li F., Qian Z.M., Sun H.Z.* (2004) “Structure and topology of the transmembrane domain 4 of the divalent metal transporter in membrane-mimetic environments” European Journal of Biochemistry, 271(10), 1938-1951. doi: 10.1111/j.1432-1033.2004.04104.x.

  4. Sun H.Z.*, Zhang L., Szeto K.Y. (2004) “Bismuth in medicine” Metal Ions in Biological System, 41, 333-378. (Featured on the cover of the issue)

  5. Li F., Sun H.Z.* “Dynamic and kinetic aspects of metallodrugs by NMR” in Fluxional Organometallic and Coordination Chemistry (Edited by Gielen M., Willem R., Wrackmeyer B.), John-Wiley & Sons, 163-217, 2004. doi: 10.1002/0470858451.ch5.

  6. Jin L., Szeto K.Y., Zhang L., Du W.H., Sun H.Z.* (2004) “Inhibition of alcohol dehydrogenase by bismuth” Journal of Inorganic Biochemistry, 98(8), 1331-1337. doi: 10.1016/j.jinorgbio.2004.03.016.

  7. Liu C.L., Wang M., Zhang T.L., Sun H.Z. (2004) “DNA hydrolysis promoted by di- and multi-nuclear metal complexes” Coordination Chemistry Reviews, 248(1-2), 147-168. doi: 10.1016/j.cct.2003.11.002.

​

2003

  1. Zheng Q., Yang W.M., Yu W.H., Cai B., Teng X.C., Yi X., Sun H.Z., Zhang M.J., Huang Z.X. (2003) “The effect of EAAEAE insert on property of human metallothionein-3” Protein Engineering, 16(12), 865-870. doi: 10.1093/protein/gzg127.

  2. Li W., Jin L., Zhu N.Y., Hou X.M., Deng F., Sun H.Z.* (2003) “Structure of colloidal bismuth subcitrate in dilute HCl:  assembly of dinuclear [Bi(cit)2Bi]2-” Journal of the American Chemical Society, 125(41), 12408-12409. doi: 10.1021/ja037019x.

  3. Li H.Y., Li F., Sun H.Z.*, Qian Z.M. (2003) “Membrane-inserted conformation of transmembrane domain4 of divalent metal transporter” Biochemical Journal, 372(Pt 3), 757-766. doi: 10.1042/bj20030075.

  4. Yan S.C., Li F., Ding K.Y., Sun H.Z.* (2003) “Reduction of pentavalent antimony and formation of binary and ternary complex with trypanothione” Journal of Biological Inorganic Chemistry, 8(6), 689-697. doi: 10.1007/s00775-003-0468-1.

  5. Sun H.Z.*, Szeto K.Y. (2003) “Binding of bismuth to serum proteins: implication for targets of Bi(III) in blood plasma”. Journal of Inorganic Biochemistry, 94(1-2), 114-120. doi: 10.1016/S0162-0134(02)00649-9.

  6. Che C.-M.*, Sun R.W.Y., Yu W.Y., Ko B.C.B., Zhu N.Y., Sun H.Z.* (2003) “Gold(III) porphyrins as a new class of anticancer drugs: cytotoxicity, DNA binding and induction of apoptosis in human cervix epitheloid cancer cells” Chemical Communications, (14), 1718-1719. doi: 10.1039/B303294A.

  7. Lo W.Y., Lam C.H., Fung W.K.M., Sun H.Z., Yam V.W.W., Balcells D., Maseras F., Eisenstein O. (2003) “An oscillating C22- unit inside a copper rectangle” Chemical Communications, (11), 1260-1261. doi: 10.1039/B301842C.

  8. Yan S.C., Wong L.K., Chow L.M.C., Sun H.Z.* (2003) “Rapid reduction of pentavalent antimony by trypanothione: potential relevance to antimonial activation” Chemical Communications, (2), 266-267. doi: 10.1039/B210240D.

​

2002

  1. Du X.L., Zhang T.L., Yuan L., Zhao Y.Y., Li R.C., Wang K., Yan S.C., Zhang L., Sun H.Z. Qian Z.M. (2002) “Complexation of ytterbium to human transferrin and its uptake by K562 cells” European Journal of Biochemistry, 269(24), 6082-6090. doi: 10.1046/j.1432-1033.2002.03326.x.

  2. Sun H.Z.* (2002) “Metallodrugs” in Encyclopedia of Nuclear Magnetic Resonance: Advances in NMR (Ed: Grant, D.M. & Harris R.K., John Wiley & Sons Ltd.), 413-427.

  3. Li H.Y., Sun H.Z., Qian Z.M. (2002) “Drug delivery and targeting: the role of transferrin/transferrin receptor system” Trends in Pharmacological Sciences, 23(5), 206-209. doi: 10.1016/S0165-6147(02)01989-2.

  4. Sun H.Z.*, Zhang L., Szeto K.Y. (2002) “Basis of bismuth antiulcers: biological chemistry and pharmacology”. Chinese Journal of Clinical Pharmacology, 18, 297-301. doi: 10.3969/j.issn.1001-6821.2002.04.015.

  5. Zhang R., Yu W.Y., Sun H.Z., Liu W.S., Che C.M. (2002) “Stereo- and enantioselective alkene epoxidations: a comparative study of D4- and D2-symmetric homochiral trans-dioxoruthenium(VI) porphyrins” Chemistry, A European Journal, 8(11), 2495-2507. doi: 10.1002/1521-3765(20020603)8:11<2495::AID-CHEM2495>3.0.CO;2-G.

  6. Qian Z.M., Li H.Y., Sun H.Z., Ho K. (2002) “Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway” Pharmacological Reviews, 54(4), 561-587. doi: 10.1124/pr.54.4.561. (Featured on the cover of the issue)

​

2001

  1. Zhang L., Szeto K.Y., Wong W.B., Sadler P.J., Sun H.Z.* (2001) “Interactions of bismuth with human lactoferrin and recognition of Bi(III)-lactoferrin by intestinal cells” Biochemistry, 40(44), 13281-13287. doi: 10.1021/bi010579t.

  2. Sun H.Z., Li H.Y., Mason A.B., Woodworth R.C., Sadler P.J. (2001) “Competitive binding of bismuth to transferrin and albumin in aqueous solution and blood plasma” Journal of Biological Chemistry, 276(12), 8829-8835. doi: 10.1074/jbc.M004779200.

​

2000​

  1. Sun H.Z.*, Yan S.-C., Cheng W.-S. (2000) “Interaction of antimony tartrate with the tripeptide glutathione: implication for its mode of action” European Journal of Biochemistry, 267(17), 5450-5457. doi: 10.1046/j.1432-1327.2000.01605.x.

  2. Yan S.C., Ding K., Zhang L., Sun H.Z.* (2000) “Complexation of antimony(III) to trypanothione” Angewandte Chemie International Edition, 39(23), 4260-4262. doi: 10.1002/1521-3773(20001201)39:23<4260::AID-ANIE4260>3.0.CO;2-9.

  3. Guo M.L., Sun H.Z., McArdle H. J., Gambling L., Sadler P. J. (2000) “TiIV uptake and release by human serum transferrin and recognition of TiIV-transferrin by cancer cells: understanding the mechanism of the anticancer agent titanocene dichloride” Biochemistry, 39(33), 10023-10033. doi: 10.1021/bi000798z.

  4. Guo M.L., Sun H.Z., Bihari S., Parkinson J.A., Gould R.O., Parsons S., Sadler P.J. (2000) “Stereoselective formation of seven-coordinate titanium(IV) monomer and dimer complexes of ethylenebis(o-hydroxyphenyl)glycine” Inorganic Chemistry, 39(2), 206-215. ​doi: 10.1021/ic990669a.

​

1999​

  1. Sun H.Z., Li H.Y., Sadler P. J. (1999) “Transferrin as a metal ion-mediator” Chemical Reviews, 99(9), 2817-2842. doi: 10.1021/cr980430w.

  2. Sun H.Z., Sadler P.J. (1999) “Bismuth anti-ulcer complexes” Topics in Biological Inorganic Chemistry, 2, 159-186. doi: 10.1007/978-3-642-60061-6_5.

  3. Sun H.Z., Li H.Y., Harvey I., Sadler P.J. (1999) “Interactions of bismuth complexes with metallothionein (II)” Journal of Biological Chemistry, 274(41), 29094-29101. doi: 10.1074/jbc.274.41.29094.

  4. Sun H.Z., Li H.Y., Mason A.B., Woodworth R.C., Sadler P.J. (1999) “N-lobe versus C-lobe complexation of bismuth by human transferrin” Biochemical Journal, 337(Pt 1), 105-111. 

  5. Sadler P.J., Li H.Y., Sun H.Z. (1999) “Coordination chemistry of metals in medicine: target sites for bismuth” Coordination Chemistry Reviews, 185-186, 689-709. doi: 10.1016/S0010-8545(99)00018-1.

​

1998

  1. Sun H.Z., Li H.Y., Weir R.A., Sadler P.J. (1998) “The first specific Ti(IV) protein complex: potential relevance to anticancer activity of titanocenes” Angewandte Chemie International Edition, 37(11), 1577-1579. doi: 10.1002/(SICI)1521-3773(19980619)37:11<1577::AID-ANIE1577>3.0.CO;2-M. (Highlighted in Chem&Engn News, 1998, June 22, p27) 

  2. Sun H.Z., Cox M.C., Li H.Y., Mason A.B., Woodworth R.C., Sadler P.J. (1998) “[1H, 13C] NMR determination of the order of lobe loading of human transferrin with iron: comparison with other metal ions” FEBS Letters, 422(3), 315-320. doi: 0.1016/S0014-5793(98)00034-9. (Featured on the cover of the issue)

  3. Parkinson J.A., Sun H.Z., Sadler P.J. (1998) “New approach to the solution chemistry of bismuth citrate antiulcer complexes” Chemical Communications, (8), 881-882. doi: 10.1039/A708710A.

  4. Daniels M. J., Turner-Cavet J. S., Selkirk R., Sun H.Z., Parkinson J.A., Sadler P.J., Robinson N.J. (1998)  “Coordination of Zn2+ (and Cd2+) by prokaryotic metallothionein: involvement of his-imidazole”. Journal of Biological Chemistry, 273(36), 22957-22961. doi: 10.1074/jbc.273.36.22957.

​

1997

  1. Sun H.Z.*, Cox M.C., Li H.Y., Sadler P.J.* (1997) “Rationalization of metal binding to transferrin: prediction of metal-protein stability constants” Structure & Bonding, 88, 71-102.  doi: 10.1007/3-540-62870-3_3.

  2. Sun H.Z., Li H.Y., Sadler P. J. (1997) “The biological and medicinal chemistry of bismuth(III)” Chemische Berichte, 130, 669-681. doi: 10.1002/cber.19971300602.

  3. Li H.Y., Keohane B.M., Sun H.Z., Sadler P. J. (1997) “Determination of bismuth in plasma and urine by DIN-ICP-MS”. Journal of Analytical Atomic Spectrometry, 12(10), 1111-1114.  doi: 0.1039/A700269F.

​

1996

  1. Sadler P. J., Sun H.Z., Li H.Y. (1996) “Bi(III) complexes of the tripeptide glutathione (γ-L-Glu-L-Cys-Gly)” Chemistry, a European Journal, 2(6), 701-708.  doi: 10.1002/chem.19960020615.

  2. Li H.Y., Sadler P. J., Sun H.Z. (1996) “Rationalization of the strength of metal binding to human serum transferrin” European Journal of Biochemistry, 242(2), 387-393. (Highlighted in Chemtracts-Inorganic Chemistry, 1997, 10, 896-901. doi: 10.1111/j.1432-1033.1996.0387r.x.

  3. Li H.Y., Sadler P. J., Sun H.Z. (1996) “Unexpectedly strong binding of a large metal ion (Bi3+) to human serum transferrin” Journal of Biological Chemistry, 271(16), 9483-9489. 

  4. Barrie P.J., Djuran M.I., Mazid M. A., McPartlin M., Sadler P.J., Scowen I.J., Sun H.Z. (1996) “Solid-state 13C NMR investigation of bismuth citrate complexes and crystal structure of  [Na2Bi2(cit)2]·7H2O” Journal of Chemical Society, Dalton Transactions, (12), 2417-2422. 

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1995

  1. Sadler P.J., Sun H.Z. (1995) “Ranitidine bismuth(III) citrate”. Journal of Chemical Society, Dalton Transactions, (9), 1395-1401. doi: 10.1039/DT9950001395.

  2. Shao W., Sun H.Z., Yao, Y.M., Tang, W.X. (1995) “1H NMR studies of the imidazole complex of cytochrome-c - resonance assignment and structural characterization of the heme cavity” Inorganic Chemistry, 34(3), 680-687. doi: 10.1021/ic00107a023.

​

1993

  1. Chen H.L., Yan H., Sun H.Z., Tang W.X. (1993) "Synthesis and characterization of coenzyme-B12 analogs containing 2’-deoxynucleoside” Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry, 23(3), 347-358. doi: 10.1080/15533179308016642.

  2. Yan H., Sun H.Z., Chen H.L., Tang W.X. (1993) “2D 1H NMR studies on 2’5’-dideoxy adenosylcobalamin” Spectroscopy Letter, 26(2), 319-329. doi: 10.1080/00387019308011534.

  3. Ding D.Y., Sun H.Z., Tang W.X. (1993) “Assignment of nonexchangeable proton resonances and the solution structure of d(TGGGT)” Spectroscopy Letter, 26(8), 1537-1546. doi: 10.1080/00387019308011632.

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1992

  1. Sun H.Z., Shao W.P., Tang W.-X., Wang X.C. (1992) “The study of conformations in solution for gastrin with 2D NMR” Acta Chimica Sinica, 50, 281-287. doi: 10.1016/0006-291X(88)90429-9.

​

Department of Chemistry, The University of Hong Kong

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