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Book Pages

Publications (2016-2023)

2024

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  1. Xia, Y., Wei, X., Gao, P., Wang, C., de Jong, A., Chen, J.H.K., Rodríguez-Sánchez, M.J., Rodríguez-Nogales, A., Diez-Echave, P., Gálvez, J. and García, F., 2024. "Bismuth-based drugs sensitize Pseudomonas aeruginosa to multiple antibiotics by disrupting iron homeostasis". Nature Microbiology, pp.1-14, doi: https://doi.org/10.1038/s41564-024-01807-6

  2. Li, Y.F. and Sun, H. eds., 2024. Applied Metallomics: From Life Sciences to Environmental Sciences. John Wiley & Sons. ISBN: 978-3-527-84038-0

  3. Zhou, Y., Li, H., Tse, E. and Sun, H., 2024. "Metal-detection based techniques and their applications in metallobiology." Chemical Science, 15(27), pp.10264-10280. doi:  10.1039/D4SC00108G

  4. Wei, X., Chan, C.L., Zhou, Y., Tang, K., Chen, J., Wang, S., Chan, J.F.W., Yuan, S., Li, H. and Sun, H., 2024. “Mechanistic insights into bismuth (III) inhibition of SARS-CoV-2 helicase.” Chemical Science, 15, 10065-10072. doi: 10.1039/D3SC06961C

  5. Casini, A., Chao, H., Sun, H. and Chang, C.J., 2024. Introduction to “Chemical biology of metals”. RSC Chemical Biology, 5(6), pp.481-482. doi: 10.1039/D4CB90017K

  6. Shi, L., Lu, J., Xia, X., Liu, X., Li, H., Li, X., Zhu, J., Li, X., Sun, H. and Yang, X., 2024. "Clinically used drug arsenic trioxide targets XIAP and overcomes apoptosis resistance in an organoid-based preclinical cancer model". Chemical Science.15, 8311-8322. doi: 10.1039/D4SC01294A

  7. Zhou, Y., Cheng, T., Tang, K., Li, H., Luo, C., Yu, F., Xiao, F., Jin, L., Hung, I.F.N., Lu, L. and Yuen, K.Y., 2024. "Integration of metalloproteome and immunoproteome reveals a tight link of iron-related proteins with COVID-19 pathogenesis and immunity". Clinical Immunology, 263, p.110205. doi: 10.1016/j.clim.2024.110205

  8. Chen, J., Zhou, Y., Wei, X., Xu, X., Qin, Z., Ong, C.P., Ye, Z.W., Jin, D.Y., Boitrel, B., Yuan, S. and Chan, J.F.W., 2023. "Development of Pan-Anti-SARS-CoV-2 Agents through Allosteric Inhibition of nsp14/nsp10 Complex". ACS Infectious Diseases, 10(3), pp.858-869. doi: 10.1021/acsinfecdis.3c00356

  9. Zhou, Y., Shen, W., Gao, Y., Peng, J., Li, Q., Wei, X., Liu, S., Lam, F.S., Mayol-Llinàs, J., Zhao, G. and Li, G., 2024. "Protein-templated ligand discovery via the selection of DNA-encoded dynamic libraries". Nature Chemistry, 16(4), pp.543-555. doi: 10.1038/s41557-024-01442-y

  10. Lu, J., Liu, X., Li, X., Li, H., Shi, L., Xia, X., He, B.L., Meyer, T.F., Li, X., Sun, H. and Yang, X., 2024. "Copper regulates the host innate immune response against bacterial infection via activation of ALPK1 kinase". Proceedings of the National Academy of Sciences, 121(4), p.e2311630121. doi: 10.1073/pnas.2311630121

 

2023

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  1. ​Gao, P., Wei, Y., Hou, S., Lai, P.M., Liu, H., Tai, S.S.C., Tang, V.Y.M., Prakash, P.H., Sze, K.H., Chen, J.H.K. and Sun, H., 2023. "SaeR as a novel target for antivirulence therapy against Staphylococcus aureus". Emerging Microbes & Infections, 12(2), p.2254415. doi: 10.1080/22221751.2023.2254415​

  2. Mo, Y., Yue, M., Yim, L.Y., Zhou, R., Yu, C., Peng, Q., Zhou, Y., Luk, T.Y., Lui, G.C.Y., Huang, H. and Lim, C.Y.H., 2023. "Nicotinamide mononucleotide impacts HIV-1 infection by modulating immune activation in T lymphocytes and humanized mice". EBioMedicine, 98. doi: 10.1016/j.ebiom.2023.104877

  3. Zhou Y, Yuan S, Xiao F, Li H, Ye Z, Cheng T, Luo C, Tang K, Cai J, Situ J, Sridhar S, Chu WM, Tam AR, Chu H, Che CM, Jin L, Hung IF, Lu L, Chan JF, Sun H. "Metal-coding assisted serological multi-omics profiling deciphers the role of selenium in COVID-19 immunity". Chemical Science. 2023 Sep 18;14(38):10570-10579. doi: 10.1039/d3sc03345g

  4. Wang, C., Xia, Y., Wang, R., Li, J., Chan, C.L., Kao, R.Y.T., Toy, P.H., Ho, P.L., Li, H. and Sun, H., 2023. "Metallo-sideromycin as a dual functional complex for combating antimicrobial resistance". Nature Communications, 14(1), p.5311. doi: 10.1038/s41467-023-40828-3

  5. He, X., Han, B., Wang, R., Guo, Y., Kao, R.Y., Li, H., Sun, H. and Xia, W., 2023. "Dual-action gallium-flavonoid compounds for combating Pseudomonas aeruginosa infection". RSC Chemical Biology, 4(10), pp.774-784. doi: 10.1039/d3cb00033h

  6. Chen, C., Xu, Y., Oelschlaeger, P., Brem, J., Liu, L., Wang, D., Sun, H. and Yang, K.W., 2023. "A dual covalent binder for labelling and inhibiting serine and metallo-carbapenemases". Chemical Communications, 59(60), pp.9227-9230. doi: 10.1039/d3cc02373g

  7. Ip, T.K.Y., Zhou, Y., Li, H. and Sun, H., 2023. "Metalloproteomics: A Powerful Technique for Metals in Medicine". In Targeted Metallo-Drugs (pp. 265-288). CRC Press. 

  8. ​Bhattarai, A., Lok, J.G.T., Sun, H. and Vardhanabhuti, V., 2023. "Computed Tomography of Cartilage: An Exploration of Novel Cationic Bismuth Contrast Agent". Annals of Biomedical Engineering, 51(5), pp.977-986. doi: 10.1007/s10439-022-03110-z​

  9. Bhattarai, A.; Lok, J. G.-T.; Sun, H.; Vardhanabhuti, V. "Photon counting spectral computed tomography in diagnosis of joint conditions using novel bismuth contrast agent". Medical Imaging 2023: Physics of Medical Imaging, 2023; SPIE: Vol. 12463, pp 20-25. doi: 10.1117/12.2653234

  10. Wang, H.; Hu, L.; Li, H.; Lai, Y.-T.; Wei, X.; Xu, X.; Cao, Z.; Cao, H.; Wan, Q.; Chang, Y.-Y.; Xu, A.; Zhou, Q.; Jiang, G.; He, M.-L.; Sun, H. "Mitochondrial ATP Synthase as a Direct Molecular Target of Chromium(Iii) to Ameliorate Hyperglycaemia Stress". Nature Communications 2023, 14 (1). DOI:10.1038/s41467-023-37351-w.

  11. Yang, P.; Pan, J.; Wang, H.; Xiaohan, X.; Zeling, X.; Chen, X.; Yang, Y.; Sun, H.; Li, M.; Habimana, O. "Structural, Metagenomic and Metabolic Shifts in Multispecies Freshwater Biofilm Models Exposed to Silver Nanoparticles". Journal of Environmental Chemical Engineering 2023, 11 (1), 109162. DOI:10.1016/j.jece.2022.109162.

  12. Huang, R.; Zhou, Z.; Lan, X.; Tang, F. K.; Cheng, T.; Sun, H.; Cham-Fai Leung, K.; Li, X.; Jin, L. "Rapid Synthesis of Bismuth-Organic Frameworks as Selective Antimicrobial Materials against Microbial Biofilms". Materials Today Bio 2023, 18, 100507. DOI:10.1016/j.mtbio.2022.100507.

  13. Zhang, Q.; Wang, M.; Hu, X.; Yan, A.; Ho, P.-L.; Li, H.; Sun, H. "Gold Drugs as Colistin Adjuvants in the Fight against MCR-1 Producing Bacteria". JBIC Journal of Biological Inorganic Chemistry 2023, 28 (2), 225–234. DOI:10.1007/s00775-022-01983-y.

  14. Yan, X.; Zhou, Y.; Li, H.; Jiang, G.; Sun, H. "Metallomics and Metalloproteomics". Comprehensive Inorganic Chemistry III 2023, 53–76. DOI:10.1016/b978-0-12-823144-9.00060-1.

 

2022

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  1. Bhattarai, A.; Lok, J. G.-T.; Sun, H.; Vardhanabhuti, V. "Computed Tomography of Cartilage: An Exploration of Novel Cationic Bismuth Contrast Agent". Annals of Biomedical Engineering 2022, 51 (5), 977–986. DOI:10.1007/s10439-022-03110-z.

  2. Mohamadi, A.; Cheng, T.; Jin, L.; Wang, J.; Sun, H.; Koohi-Moghadam, M. "An Ensemble 3D Deep-Learning Model to Predict Protein Metal-Binding Site". Cell Reports Physical Science 2022, 3 (9), 101046. DOI:10.1016/j.xcrp.2022.101046.

  3. Zhou Y., Li H.Y., Sun H.Z.* "Metalloproteomics for biomedical research: methodology and applications”. Annual Review of Biochemistry (Editor: Kornberg, R.), , doi: 10.1146/annurev-biochem-040320-104628

  4. Zhang Q.§, Wang R.M.§, Wang M.J., Liu C.J., Koohi-Moghadam M., Wang H.B., Ho P.L., Li H.Y., Sun H.Z.* "Re-sensitization of mcr carrying multidrug resistant bacteria to colistin by silver". Proceedings of the National Academy of Sciences USA, 119 (11) e2119417119, doi: 10.1073/pnas.2119417119

  5. Li H.Y., Sun H.Z.* "A hydroxide lock for metallo-β-lactamases" . Nature Chemistry, 14, 6-8, doi: 10.1038/s41557-021-00871-3

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2021

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  1. Wang R.M.§, Chan J.F.W.§, Wang S.Y.§, Li H.Y., Zhao J.J., Ip T.K.Y., Zuo J.Z., Yuen K.Y., Yuan S.F., Sun H.Z.* "Orally administrated bismuth drug together with N-acetyl cysteine as a broad-spectrum anti-coronavirus cocktail therapy". Chemical Science, 13, 2238-2248, doi: 10.1039/D1SC04515F.

  2. Yan X.T.,  Zhou Y., Jiang G.B., Li H.Y., Sun H.Z.* "Metallomics and metalloproteomics", in Comprehensive Inorganic Chemistry III (Editor: Pecoraro, V.P., Guo, Z.J.), accepted

  3. Zhou Y., Tse E.W.C., Leung R., Cheung E., Li H.Y., Sun H.Z.* "Multiplex single-cell analysis of cancer cells enables unbiased uncovering subsets associated with cancer relapse: heterogeneity of multidrug resistance in precursor B-ALL", ChemMedChem, 16, doi: /10.1002/cmdc.202100638.

  4. Wang C., Li X., Cheng T.F., Sun H.Z., Jin L.J.* "Eradication of porphyromonas gingivalis persisters through colloidal bismuth subcitrate synergistically combined with metronidazole", Frontiers in Microbiology, 12, 748121, doi: 10.3389/fmicb.2021.748121.

  5. Li Y.F.*, Sun H.Z. "Metallomics in multidisciplinary research and the analytical advances", Atomic Spectroscopy, 42(5), 227-230, doi: 10.46770/AS.2021.108.

  6. Zhao J.T., Wang L.M., Cui L.W., Sun H.Z.*, Gao Y.X., Li Y.F.* "Metallomics for the screening of COVID-19 and metallodrug development", Atomic Spectrscopy, 42(5), 231-237, doi: 10.46770/AS.2021.805. 

  7. Griffith D.§, Li H.Y.§, Werrett M.W., Andrews P., Sun H.Z.* "Medicinal chemistry and biomedical applications of bismuth-based compounds", Chemical Society Review, 50(21), 12037-12069, doi: 10.1039/D0CS00031K.

  8. Hu X.Q.§, Li H.Y.§, Ip T.K.Y., Cheung Y.F., Koohi-Moghadam M., Wang H.B., Yang X.M., Tritton D. N., Wang Y.C., Wang Y., Wang R.M., Ng K.M., Naranmandura H., Tse E.W.C., Sun H.Z.* "Arsenic trioxide targets Hsp60, triggering degradation of p53 and survivin".  Chemical Science, 12(32), 10893-10900, doi: 10.1039/D1SC03119H

  9. Maimaitiyiming Y., Wang Q.Q., Yang C., Ogra Y., Lou Y.J., Smith C.A., Hussain L., Shao Y.M., Lin J.B., Liu J.F., Wang L.F., Zhu Y., Lou H.Y., Huang Y., Li X.X., Chang K.J., Chen H. Li H.Y., Huang, Y., Tse, E., Sun, J., Bu, N., Chiou, S.H., Zhang, E.F, Hua, H.Y., Ma, L.Y., Huang, P., Ge, M.H., Cao F.L., Cheng X.D., Sun H.Z., Zhou J., Vasliou V., Xu P., Jin J., Bjorklund M., Zhu H.H., Hsu C.H., Naranmandura H.* "Hyperthermia selectively destabilizes ongoneic fusion proteins". Blood Cancer Discovery, 2(4), 388-401, doi: 10.1158/2643-3230.BCD-20-0188. 

  10. Wang H.B., Wang M.J., Xu X.H., Gao P., Xu Z.L., Zhang Q., Li H.Y., Yan A.X., Kao R.Y. -T., Sun H.Z.* “Multi-target mode of action of silver against Staphylococcus aureus endows it with capability to combat antibiotic resistance”. Nature Communications, 12, 3331, doi: 10.1038/s41467-021-23659-y.

  11. Yuan S.F., Yin X., Meng X.Z., Chan J.F.W., Ye Z.W., Riva L., Pache L., Chan C.C.Y., Lai P.M., Chan C.C.S., Poon V.K.M., Lee A. C.Y., Matsunaga N., Pu Y., Yuen C.K., Cao J.L., Liang R.H., Tang K.M., Sheng L., Du Y.S., Xu W., Lau C.Y., Sit K.Y., Au W.K., Wang R.M., Zhang Y.Y., Tang Y.D., Clausen T.M., Pihl J., Oh J., Sze K.H., Zhang A.J.X., Chu H., Kok K-H., Wang D., Cai X.H., Esko J.D., Hung I.F.N., Li R.A., Chen H.L., Sun H.Z., Jin D.Y., Sun R., Chanda S.K., Yuen K.Y.* (2021) “Clofazimine is a broad-spectrum coronavirus inhibitor that antagonizes SARS-CoV-2 replication in primary human cell culture and hamsters”. Nature, 593, 418-423. doi: 10.1038/s41586-021-03431-4. 

  12. Xu X.H.§, Wang H.B.§, Li H.Y., Sun H.Z.* (2021) “Dynamic and temporal transcriptomic analysis reveals ferroptosis-mediated anti-leukemia activity of S-dimethylarsino-glutathione: insights into novel therapeutic strategy” CCS Chemistry, 3, 1089-1100. doi: 10.31635/ccschem.021.202000685.

  13. Tse E.C.M.*, Sun H.Z.* (2020) Book review for “Transition Metals and Sulfur –A Strong Relationship for Life”, Metal Ions in Life Sciences, vol. 20, Zeitschrift für Naturforschung C, 76(5-6)c, 257-259, doi: 10.1515/znc-2020-0252.

  14. Zhou Y., Ip T.K.Y., Zhang Q., Li H.Y., Sun H.Z.* (2020) “Metal complexes as drugs and chemotherapeutic agents” in Comprehensive Coordination Chemistry III (Volume 9: “Applications of Coordination Chemistry”), 680-705, Elsevier. doi: 10.1016/B978-0-08-102688-5.00018-0.

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​2020

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  1. Wang H.B.*, Yang X.M., Wang M.J., Xu X.H., Hu M.L, Yan A.X., Hao Q., Li H.Y., Sun H.Z.* (2020) “Atomic differentiation of silver binding preference in protein targets: Escherichia coli malate dehydrogenase as a paradigm” Chemical Science, 11(43), 11714-11719. doi: 10.1039/D0SC04151C.

  2. Yuan S.F.§, Wang R.M.§, Chan J.F.W.§, Zhang A.J., Cheng T.F., Chik K.K.H., Ye Z.W., Wang S.Y., Lee A.C., Jin L.J., Li H.Y., Jin D.Y., Yuen K.Y.*, Sun H.Z.* (2020) “Metallodrug ranitidine bismuth citrate suppress SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters” Nature Microbiology, 5(11), 1439-1448. doi: 10.1038/s41564-020-00802-x.

  3. Sun H.Z.§*, Zhang Q.§, Wang R.M.§*, Wang H.B., Wong Y.T., Wang M.J., Hao Q., Yan A.X., Kao R.Y.T., Ho P.L., Li H.Y. (2020) “Resensitizing carbapenem- and colistin-resistant bacteria to antibiotics using auranofin” Nature Communications, 11(1), 5263, doi: 10.1038/s41467-020-18939-y.

  4. Wang R.M., Wang S.Y., Chan S., Zuo Z., Chan G.C.F., Li H.Y., Sun H.Z.* (2020) “Bismuth porphyrin antagonizes cisplatin-induced nephrotoxicity via inactivating caspase-dependent apoptotic pathway” iScience, 23(5), 101054. doi: 10.1016/j.isci.2020.101054.

  5. Tao X., Zhang Z.M., Zhang X., Li H.Y., Sun H.Z.*, Mao Z.W., Xia W.* (2020) “Structural insight into the substrate gating mechanism by Staphylococcus aureus aldehyde dehydrogenase” CCS Chemistry, 2(3), 946-954. doi: 10.31635/ccschem.020.202000219.

  6. Xu X.H., Wang H.B., Li H.Y., Sun H.Z.* (2020) “Metalloproteomic approaches for matching metals to proteins: The power of inductively coupled plasma mass spectrometry (ICP-MS)” Chemistry Letter, 49(6), 697-704. doi: 10.1246/cl.200155. (invited, featured on the front cover)

  7. Kanatzidis M., Sun H.Z., Dehnen S.* (2020) “Bismuth- the magic element” Inorganic Chemistry, 2020, 59(6) 3341-3343. doi: 10.1021/acs.inorgchem.0c00222. (editorial)

  8. Wang H.B., Zhou Y., Xu X.H., Li H.Y., Sun H.Z.* (2020) “Metalloproteomics in conjunction with other omics for uncovering the mechanism of action of metallodrugs: mechanism-driven new therapy development” Current Opinion in Chemical Biology, 55, 171-179. doi: 10.1016/j.cbpa.2020.02.006. (invited)

  9. Wang R.M., Li H.Y., Ip T.K.Y., Sun H.Z.* (2020) “Chapter 6 − Bismuth drugs as antimicrobial agents” Advances in Inorganic Chemistry, 75, 183-205. doi: 10.1016/bs.adioch.2019.10.011.

  10. Jiang N., Wang Y.L., Chan K.C., Sun H.Z.*, Li G.J.* (2020) “Additive manufactured graphene coating with synergistic photothermal and superhydrophobic effects for bactericidal applications” Global Challenges, 4(1), 1900054. doi: 10.1002/gch2.201900054.

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